| pubmed-article:19758697 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19758697 | lifeskim:mentions | umls-concept:C0023452 | lld:lifeskim |
| pubmed-article:19758697 | lifeskim:mentions | umls-concept:C0034809 | lld:lifeskim |
| pubmed-article:19758697 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:19758697 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:19758697 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:19758697 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19758697 | pubmed:dateCreated | 2010-2-22 | lld:pubmed |
| pubmed-article:19758697 | pubmed:abstractText | Childhood acute lymphoblastic leukemia patients (n=310) were analyzed for four SNPs in the NR3C1 gene. Polymorphisms -627A/G, intron 2 +646C/G and 9bT/C were all associated with reduced event-free survival. Haplotypes composed of AGT alleles at these loci and tagged by the intron 2 +646G variant also associated with lower event-free survival (p=0.03). The progressive impact of this haplotype on outcome was seen with two copies associated with reduced overall survival (p=0.05). Quantitative mRNA analysis in lymphoblastoid cell lines showed that carriers of the AGT haplotype had a higher ratio of GR gamma/alpha isoforms (p=0.04), which possibly explains its association with reduced event-free survival and overall survival. | lld:pubmed |
| pubmed-article:19758697 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19758697 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19758697 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19758697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19758697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19758697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19758697 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19758697 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19758697 | pubmed:issn | 1873-5835 | lld:pubmed |
| pubmed-article:19758697 | pubmed:author | pubmed-author:MoghrabiAlber... | lld:pubmed |
| pubmed-article:19758697 | pubmed:author | pubmed-author:KrajinovicMaj... | lld:pubmed |
| pubmed-article:19758697 | pubmed:author | pubmed-author:SinnettDaniel... | lld:pubmed |
| pubmed-article:19758697 | pubmed:author | pubmed-author:GagnéVincentV | lld:pubmed |
| pubmed-article:19758697 | pubmed:author | pubmed-author:LabudaMalgorz... | lld:pubmed |
| pubmed-article:19758697 | pubmed:author | pubmed-author:GahierAnnabel... | lld:pubmed |
| pubmed-article:19758697 | pubmed:copyrightInfo | Copyright (c) 2009 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:19758697 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19758697 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:19758697 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19758697 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19758697 | pubmed:pagination | 492-7 | lld:pubmed |
| pubmed-article:19758697 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:meshHeading | pubmed-meshheading:19758697... | lld:pubmed |
| pubmed-article:19758697 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19758697 | pubmed:articleTitle | Polymorphisms in glucocorticoid receptor gene and the outcome of childhood acute lymphoblastic leukemia (ALL). | lld:pubmed |
| pubmed-article:19758697 | pubmed:affiliation | Centre de recherche Charles Bruneau, Montréal, Québec, Canada. | lld:pubmed |
| pubmed-article:19758697 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19758697 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2908 | entrezgene:pubmed | pubmed-article:19758697 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19758697 | lld:entrezgene |
