| pubmed-article:19732063 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19732063 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:19732063 | lifeskim:mentions | umls-concept:C0439861 | lld:lifeskim |
| pubmed-article:19732063 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:19732063 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:19732063 | lifeskim:mentions | umls-concept:C0013058 | lld:lifeskim |
| pubmed-article:19732063 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:19732063 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:19732063 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:19732063 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19732063 | pubmed:dateCreated | 2009-9-7 | lld:pubmed |
| pubmed-article:19732063 | pubmed:abstractText | (13)C-urea may be a suitable marker to assess the in vivo fate of colon-targeted dosage forms given by mouth. We postulated that release in the colon (urease-rich segment) of (13)C-urea from colon-targeted capsules would lead to fermentation of (13)C-urea by bacterial ureases into (13)CO(2). Subsequent absorption into the blood and circulation would lead to detectable (13)C (as (13)CO(2)) in breath. If, however, release of (13)C-urea occurred in the small intestine (urease-poor segment), we expected detectable (13)C (as (13)C-urea) in blood but no breath (13)C (as (13)CO(2)). The differential kinetics of (13)C-urea could thus potentially describe both release kinetics and indicate the gastrointestinal segment of release. | lld:pubmed |
| pubmed-article:19732063 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19732063 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19732063 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19732063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19732063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19732063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19732063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19732063 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19732063 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19732063 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19732063 | pubmed:issn | 1476-5381 | lld:pubmed |
| pubmed-article:19732063 | pubmed:author | pubmed-author:StellaardFF | lld:pubmed |
| pubmed-article:19732063 | pubmed:author | pubmed-author:WoerdenbagH... | lld:pubmed |
| pubmed-article:19732063 | pubmed:author | pubmed-author:FrijlinkH WHW | lld:pubmed |
| pubmed-article:19732063 | pubmed:author | pubmed-author:BoevPP | lld:pubmed |
| pubmed-article:19732063 | pubmed:author | pubmed-author:SchellekensR... | lld:pubmed |
| pubmed-article:19732063 | pubmed:author | pubmed-author:KosterinkJ... | lld:pubmed |
| pubmed-article:19732063 | pubmed:author | pubmed-author:OlsderG GGG | lld:pubmed |
| pubmed-article:19732063 | pubmed:author | pubmed-author:LangenbergS... | lld:pubmed |
| pubmed-article:19732063 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19732063 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:19732063 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19732063 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19732063 | pubmed:pagination | 532-40 | lld:pubmed |
| pubmed-article:19732063 | pubmed:dateRevised | 2010-9-2 | lld:pubmed |
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| pubmed-article:19732063 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19732063 | pubmed:articleTitle | Proof-of-concept study on the suitability of 13C-urea as a marker substance for assessment of in vivo behaviour of oral colon-targeted dosage forms. | lld:pubmed |
| pubmed-article:19732063 | pubmed:affiliation | Department of Clinical and Hospital Pharmacy, University Medical Center Groningen, Groningen, The Netherlands. r.c.a.schellekens@apoth.umcg.nl | lld:pubmed |
| pubmed-article:19732063 | pubmed:publicationType | Journal Article | lld:pubmed |
