| pubmed-article:19709881 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19709881 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:19709881 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19709881 | lifeskim:mentions | umls-concept:C1335439 | lld:lifeskim |
| pubmed-article:19709881 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:19709881 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19709881 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:19709881 | lifeskim:mentions | umls-concept:C1553032 | lld:lifeskim |
| pubmed-article:19709881 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:19709881 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:19709881 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:19709881 | pubmed:dateCreated | 2009-9-14 | lld:pubmed |
| pubmed-article:19709881 | pubmed:abstractText | A series of benzo[d]isothiazole-1,1-dioxides were designed and evaluated as inhibitors of HCV polymerase NS5B. Structure-based design led to the incorporation of a high affinity methyl sulfonamide group. Structure-activity relationship (SAR) studies of this series revealed analogues with submicromolar potencies in the HCV replicon assay and moderate pharmacokinetic properties. SAR studies combined with structure based drug design focused on the sulfonamide region led to a novel and potent cyclic analogue. | lld:pubmed |
| pubmed-article:19709881 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19709881 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19709881 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19709881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19709881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19709881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19709881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19709881 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19709881 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19709881 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:LoyEE | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:BlakeJames... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:Le... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:BriggsAndrewA | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:RobinsonJohn... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:AdjabengGeorg... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:MohrPeterP | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:BrandlMichael... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:SmithDavid... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:LarrabeeSusan... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:RajyaguruSona... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:ElworthyTodd... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:HarrisSeth... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:AlexandrovaLu... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:WongAprilA | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:FarrellRobert... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:YeeCalvinC | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:SpencerStacey... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:SukhtankarSun... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:NajeraIsabelI | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:HendricksRobe... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:FellJay BJB | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:StengelPeter... | lld:pubmed |
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| pubmed-article:19709881 | pubmed:author | pubmed-author:FischerJohnJ | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:Ao-IeongGlori... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:HilgenkampRam... | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:WangBeihanB | lld:pubmed |
| pubmed-article:19709881 | pubmed:author | pubmed-author:BambergJoe... | lld:pubmed |
| pubmed-article:19709881 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19709881 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19709881 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19709881 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19709881 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19709881 | pubmed:pagination | 5652-6 | lld:pubmed |
| pubmed-article:19709881 | pubmed:meshHeading | pubmed-meshheading:19709881... | lld:pubmed |
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| pubmed-article:19709881 | pubmed:meshHeading | pubmed-meshheading:19709881... | lld:pubmed |
| pubmed-article:19709881 | pubmed:meshHeading | pubmed-meshheading:19709881... | lld:pubmed |
| pubmed-article:19709881 | pubmed:meshHeading | pubmed-meshheading:19709881... | lld:pubmed |
| pubmed-article:19709881 | pubmed:meshHeading | pubmed-meshheading:19709881... | lld:pubmed |
| pubmed-article:19709881 | pubmed:meshHeading | pubmed-meshheading:19709881... | lld:pubmed |
| pubmed-article:19709881 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19709881 | pubmed:articleTitle | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides. | lld:pubmed |
| pubmed-article:19709881 | pubmed:affiliation | Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. javier.devicente@roche.com | lld:pubmed |
| pubmed-article:19709881 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19709881 | lld:chembl |
