| pubmed-article:19705882 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19705882 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:19705882 | lifeskim:mentions | umls-concept:C0015083 | lld:lifeskim |
| pubmed-article:19705882 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:19705882 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:19705882 | lifeskim:mentions | umls-concept:C0596383 | lld:lifeskim |
| pubmed-article:19705882 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:19705882 | pubmed:dateCreated | 2009-8-26 | lld:pubmed |
| pubmed-article:19705882 | pubmed:abstractText | Biodegradable copolymers consisting of a hydrophilic poly[l-aspartic acid-alt-poly(ethylene glycol)] (poly(l-Asp-alt-PEG)) backbone and hydrophobic capryl units as side chains were synthesized. The amphiphilic copolymer was found to form nanosized hydrogel particles (nanogels) of approximately 15 nm in size by self-assembly at 20 degrees C in aqueous media, and the nanogel solutions displayed phase-transition in response to temperature. The transition of the nanogel solution was reversible and tunable in the range from 19 to 55 degrees C by variation of the amounts of capryl units introduced and the solution concentration. The nanogels were gradually degraded within days in a phosphate buffer solution (PBS) at 37 degrees C. Temperature-responsive biodegradable nanogel systems consisting of biocompatible PEG may have potential utility for high biocompatibility temperature-responsive nanodevices such as microreactor systems, molecular-chaperones, and drug delivery vehicles. | lld:pubmed |
| pubmed-article:19705882 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19705882 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19705882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19705882 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19705882 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19705882 | pubmed:issn | 0743-7463 | lld:pubmed |
| pubmed-article:19705882 | pubmed:author | pubmed-author:OuchiTatsuroT | lld:pubmed |
| pubmed-article:19705882 | pubmed:author | pubmed-author:OhyaYuichiY | lld:pubmed |
| pubmed-article:19705882 | pubmed:author | pubmed-author:NagahamaKojiK | lld:pubmed |
| pubmed-article:19705882 | pubmed:author | pubmed-author:HashizumeMiho... | lld:pubmed |
| pubmed-article:19705882 | pubmed:author | pubmed-author:YamamotoHidet... | lld:pubmed |
| pubmed-article:19705882 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19705882 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19705882 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:19705882 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19705882 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19705882 | pubmed:pagination | 9734-40 | lld:pubmed |
| pubmed-article:19705882 | pubmed:meshHeading | pubmed-meshheading:19705882... | lld:pubmed |
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| pubmed-article:19705882 | pubmed:meshHeading | pubmed-meshheading:19705882... | lld:pubmed |
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| pubmed-article:19705882 | pubmed:meshHeading | pubmed-meshheading:19705882... | lld:pubmed |
| pubmed-article:19705882 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19705882 | pubmed:articleTitle | Hydrophobically modified biodegradable poly(ethylene glycol) copolymers that form temperature-responsive Nanogels. | lld:pubmed |
| pubmed-article:19705882 | pubmed:affiliation | Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering and High Technology Research Center, Kansai University, Suita, Osaka 564-8680, Japan. | lld:pubmed |
| pubmed-article:19705882 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19705882 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
