Linked Life Data

19685039

Source:http://linkedlifedata.com/resource/pubmed/id/19685039

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pubmed-article:19685039pubmed:abstractTextWe have studied the association between M(3) muscarinic acetylcholine receptors (M(3)-mAChR) and protein kinase C-epsilon (PKC-epsilon) during ischemic myocardial injury using Western blot analysis and immunoprecipitation technique. Myocardial ischemia (MI) induced PKC-epsilon translocation from cytosolic to membrane fractions. This translocation participated in the phosphorylation of M(3)-mAChR in membrane fractions, which could be abolished by the inhibitor of PKC, chelerythrine chloride. On the other hand, M(3)-mAChR could also regulate the expression of PKC-epsilon in ischemic myocardium. Choline (choline chloride, an M(3) receptor agonist, administered at 15 min before occlusion) strengthened the association between PKC-epsilon and M(3)-mAChR. However, blockade of M(3)-mAChR by 4-diphenylacetoxy-N-methylpiperidine methiodide (an M(3) receptor antagonist, administered at 20 min before occlusion) completely inhibited the effect of choline on the expression of PKC-epsilon. We conclude that the translocation of PKC-epsilon is required for the phosphorylation of M(3)-mAChR; moreover, increased PKC-epsilon activity is associated with M(3)-mAChR during MI. This reciprocal regulation is likely to play a role in heart signal transduction during ischemia between ventricular myocytes.lld:pubmed
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pubmed-article:19685039pubmed:year2009lld:pubmed
pubmed-article:19685039pubmed:articleTitleReciprocal regulation between M3 muscarinic acetylcholine receptor and protein kinase C-epsilon in ventricular myocytes during myocardial ischemia in rats.lld:pubmed
pubmed-article:19685039pubmed:affiliationInstitute of Clinical Pharmacology of Second Hospital, Harbin Medical University, Key Laboratory of Heilongjiang Province, Baojian Road 157, Nangang District, Harbin, Heilongjiang Province, 150081, People's Republic of China.lld:pubmed
pubmed-article:19685039pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19685039pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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