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pubmed-article:19682743pubmed:abstractTextHistone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest, terminal differentiation, and apoptosis in a broad spectrum of human tumors and animal xenograft models. JNJ-26481585 is a hydroxamic acid derivative, second-generation pan-HDAC inhibitor that has demonstrated high potency in preclinical studies. In the current study, we demonstrated that JNJ-26481585 has antileukemia and molecular activity in leukemia cell lines and primary human leukemia cells. We also observed a synergistic effect between treatment with decitabine and JNJ-26481585. In conclusion, JNJ-26481585 is a potent second-generation pan-HDAC inhibitor with activity in human leukemia, and it is currently in clinical development.lld:pubmed
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pubmed-article:19682743pubmed:copyrightInfoCopyright 2009 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:19682743pubmed:volume34lld:pubmed
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pubmed-article:19682743pubmed:articleTitlePreclinical antileukemia activity of JNJ-26481585, a potent second-generation histone deacetylase inhibitor.lld:pubmed
pubmed-article:19682743pubmed:affiliationDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, United States.lld:pubmed
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pubmed-article:19682743pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed