| pubmed-article:1967301 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C1317598 | lld:lifeskim |
| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C0015737 | lld:lifeskim |
| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:1967301 | lifeskim:mentions | umls-concept:C1709701 | lld:lifeskim |
| pubmed-article:1967301 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1967301 | pubmed:dateCreated | 1990-2-22 | lld:pubmed |
| pubmed-article:1967301 | pubmed:abstractText | In order to investigate the prognostic significance of erbB-2 overexpression, immunohistochemical staining for the erbB-2 protein was performed on sections from paraffin blocks of 292 primary invasive breast cancers obtained from women enrolled in the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-06. Positive reaction indicative of erbB-2 overexpression was observed on tumor cells in 62 (21%) samples. Women whose cancers were judged to have erbB-2 overexpression had a significantly worse overall survival (P = .0012) with twice the mortality rate of women without detectable erbB-2 expression. No statistically significant effect was evident for disease-free survival (P = .22). In multivariate analysis, detection of erbB-2 overexpression was the second most predictive independent variable for survival after nodal status. Overexpression of erbB-2 was more common among tumors of poor nuclear grade (29%) than those of good nuclear grade (12%). The association of erbB-2 overexpression with decreased survival was evident only among women with tumors of good nuclear grade. In this subgroup, erbB-2 overexpression was associated with an approximately fivefold increase in mortality rate (P = .00001). The combined predictive value of erbB-2 overexpression and nuclear grade was evident regardless of their lymph node status. These results provide evidence that detection of erbB-2 overexpression may be an independent prognostic variable for patient survival. Moreover, when combined with evaluation of nuclear grade, it may be possible to use immunostaining for erbB-2 protein to identify patients at increased risk from within a relatively low-risk group. | lld:pubmed |
| pubmed-article:1967301 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1967301 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1967301 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1967301 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1967301 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1967301 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1967301 | pubmed:issn | 0732-183X | lld:pubmed |
| pubmed-article:1967301 | pubmed:author | pubmed-author:SchlessingerJ... | lld:pubmed |
| pubmed-article:1967301 | pubmed:author | pubmed-author:LippmanM EME | lld:pubmed |
| pubmed-article:1967301 | pubmed:author | pubmed-author:KingC RCR | lld:pubmed |
| pubmed-article:1967301 | pubmed:author | pubmed-author:FisherBB | lld:pubmed |
| pubmed-article:1967301 | pubmed:author | pubmed-author:FisherE RER | lld:pubmed |
| pubmed-article:1967301 | pubmed:author | pubmed-author:RedmondCC | lld:pubmed |
| pubmed-article:1967301 | pubmed:author | pubmed-author:PaimUU | lld:pubmed |
| pubmed-article:1967301 | pubmed:author | pubmed-author:HazanRR | lld:pubmed |
| pubmed-article:1967301 | pubmed:author | pubmed-author:SassR ERE | lld:pubmed |
| pubmed-article:1967301 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1967301 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:1967301 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1967301 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1967301 | pubmed:pagination | 103-12 | lld:pubmed |
| pubmed-article:1967301 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:1967301 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1967301 | pubmed:articleTitle | Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. | lld:pubmed |
| pubmed-article:1967301 | pubmed:affiliation | Medical Breast Cancer Section, National Cancer Institute, Bethesda, MD. | lld:pubmed |
| pubmed-article:1967301 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1967301 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1967301 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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