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| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C1705387 | lld:lifeskim |
| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C0024408 | lld:lifeskim |
| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C0752121 | lld:lifeskim |
| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C2607943 | lld:lifeskim |
| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C0008115 | lld:lifeskim |
| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C1705914 | lld:lifeskim |
| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:19672991 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:19672991 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:19672991 | pubmed:dateCreated | 2009-11-3 | lld:pubmed |
| pubmed-article:19672991 | pubmed:abstractText | To investigate the prevalence and clinical feature(s) of Parkinson's disease (PD) patients with expanded (ATXN2 and MJD1) genes of spinocerebellar ataxia type 2 and 3 (SCA2 and SCA3/MJD) in a mainland Chinese population, CAG triplet repeat expansions of (SCA2 and SCA3/MJD) genes (ATXN2 and MJD1) were analyzed in a cohort of 452 PD patients, including 386 sporadic and 66 familial forms. Striatal dopamine transporter was evaluated in two SCA2 and two SCA3/MJD-positive family members, an idiopathic PD patient and a healthy control using carbon (C11) [(11)C]-radiolabeled-CFT positron emission tomography (PET). We found two patients in one familial PD (FPD) family (1.5%) and two sporadic PD patients (0.5%) with expanded CAG repeats in the ATXN2 locus, four patients in two FPD families (3%) and another three sporadic PD patients (0.8%) in the MJD1 locus. [(11)C]-CFT PET in detected members in SCA2 and SCA3/MJD families showed decrements of (11)C-CFT uptake. These findings suggest that a mutation in SCA2 or SCA3/MJD may be one of the genetic causes of PD. | lld:pubmed |
| pubmed-article:19672991 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19672991 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19672991 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19672991 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19672991 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19672991 | pubmed:issn | 1531-8257 | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:VaryJJ | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:ShiS MSM | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:SertCC | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:HongJiangJ | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:PanQianQ | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:WangJun-LingJ... | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:TangBei-ShaBS | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:LongZhi-GaoZG | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:GuoJi-FengJF | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:SongXing-Wang... | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:YanXin-XiangX... | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:CuiXiang-Xian... | lld:pubmed |
| pubmed-article:19672991 | pubmed:author | pubmed-author:LeiLi-FangLF | lld:pubmed |
| pubmed-article:19672991 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19672991 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19672991 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:19672991 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19672991 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19672991 | pubmed:pagination | 2007-11 | lld:pubmed |
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| pubmed-article:19672991 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19672991 | pubmed:articleTitle | Analysis of SCA2 and SCA3/MJD repeats in Parkinson's disease in mainland China: genetic, clinical, and positron emission tomography findings. | lld:pubmed |
| pubmed-article:19672991 | pubmed:affiliation | Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. | lld:pubmed |
| pubmed-article:19672991 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19672991 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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