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pubmed-article:19669330pubmed:abstractTextTranscriptional silencing of tumor suppressor genes associated with DNA hypermethylation has been known as a hallmark of human cancer. In this study, we revealed that a local anesthetic, procaine (PCA), possessed growth-inhibitory and demethylating effect on human hepatoma cells in vitro and in vivo.lld:pubmed
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pubmed-article:19669330pubmed:authorpubmed-author:TokuhisaTakes...lld:pubmed
pubmed-article:19669330pubmed:authorpubmed-author:YokosukaOsamu...lld:pubmed
pubmed-article:19669330pubmed:authorpubmed-author:SakamotoAkemi...lld:pubmed
pubmed-article:19669330pubmed:authorpubmed-author:AraiMakotoMlld:pubmed
pubmed-article:19669330pubmed:authorpubmed-author:ImazekiFumioFlld:pubmed
pubmed-article:19669330pubmed:authorpubmed-author:FukaiKenichiKlld:pubmed
pubmed-article:19669330pubmed:authorpubmed-author:TadaMotohisaMlld:pubmed
pubmed-article:19669330pubmed:authorpubmed-author:MikataRintaro...lld:pubmed
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pubmed-article:19669330pubmed:articleTitleProcaine inhibits the proliferation and DNA methylation in human hepatoma cells.lld:pubmed
pubmed-article:19669330pubmed:affiliationDepartment of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, 260-8670, Japan.lld:pubmed
pubmed-article:19669330pubmed:publicationTypeJournal Articlelld:pubmed