| pubmed-article:1965847 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1965847 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:1965847 | lifeskim:mentions | umls-concept:C0205093 | lld:lifeskim |
| pubmed-article:1965847 | lifeskim:mentions | umls-concept:C1325834 | lld:lifeskim |
| pubmed-article:1965847 | lifeskim:mentions | umls-concept:C0425245 | lld:lifeskim |
| pubmed-article:1965847 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1965847 | pubmed:dateCreated | 1991-7-24 | lld:pubmed |
| pubmed-article:1965847 | pubmed:abstractText | The lateral mobility of viral envelope proteins on the plasma membranes of infected cells is an important factor in both virus assembly and pathogenesis. The envelope glycoproteins of measles and human parainfluenza virus are mobile on the surfaces of infected HeLa cells and undergo lateral redistribution in the presence of specific antibody, forming unipolar caps. In contrast, no such redistribution was observed with influenza virus hemagglutinin (HA) or vesicular stomatitis virus (VSV) G glycoproteins on infected HeLa cell surfaces. However, the HA and G glycoproteins were both found to be mobile in the plasma membrane of CV-1 cells, or human or murine peritoneal macrophages. These results indicate that host cell-dependent as well as virus-specific factors are involved in determining viral glycoprotein mobility. No significant differences in the patterns of synthesis of influenza or VSV viral proteins were found in the various cell types examined. The HA and G proteins, when expressed from vaccinia virus recombinants, were each found to be immobile in HeLa cells and mobile in CV-1 cells, thus indicating that the host cell-dependent differences in mobility are an intrinsic property of each viral glycoprotein molecule and not the result of interaction with other viral components. It is suggested that the association of viral glycoproteins with either the cytoskeleton or membrane-associated cellular proteins may be related to the observed differences in lateral mobility. | lld:pubmed |
| pubmed-article:1965847 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965847 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1965847 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965847 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1965847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965847 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1965847 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1965847 | pubmed:issn | 0882-4010 | lld:pubmed |
| pubmed-article:1965847 | pubmed:author | pubmed-author:CompansR WRW | lld:pubmed |
| pubmed-article:1965847 | pubmed:author | pubmed-author:BasakSS | lld:pubmed |
| pubmed-article:1965847 | pubmed:author | pubmed-author:LydyS LSL | lld:pubmed |
| pubmed-article:1965847 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1965847 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:1965847 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1965847 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1965847 | pubmed:pagination | 375-86 | lld:pubmed |
| pubmed-article:1965847 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:1965847 | pubmed:meshHeading | pubmed-meshheading:1965847-... | lld:pubmed |
| pubmed-article:1965847 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1965847 | pubmed:articleTitle | Host cell-dependent lateral mobility of viral glycoproteins. | lld:pubmed |
| pubmed-article:1965847 | pubmed:affiliation | Department of Microbiology, University of Alabama, Birmingham 35294. | lld:pubmed |
| pubmed-article:1965847 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1965847 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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