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pubmed-article:19635635pubmed:abstractTextFollowing the introduction of a 7-valent pneumococcal conjugate vaccine (PCV-7) for children in early 2000 in the United States, a decrease in the incidence of invasive pneumococcal disease (IPD) was seen in adults, likely due to a herd effect. However, there have been recent increases in IPD in adults caused by Streptococcus pneumoniae serotypes not included in PCV-7, so called "replacement disease". We performed a population-based study to further investigate this emerging concern.lld:pubmed
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pubmed-article:19635635pubmed:articleTitleTrends in invasive pneumococcal disease among older adults in Olmsted County, Minnesota.lld:pubmed
pubmed-article:19635635pubmed:affiliationDepartment of Medicine, Division of Infectious Diseases, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA. tsigrelis.constantine@yahoo.comlld:pubmed
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