| pubmed-article:19620326 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C1265292 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C0014118 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C0017436 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C0035608 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C0057144 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C1883712 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:19620326 | lifeskim:mentions | umls-concept:C1280519 | lld:lifeskim |
| pubmed-article:19620326 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19620326 | pubmed:dateCreated | 2009-9-22 | lld:pubmed |
| pubmed-article:19620326 | pubmed:abstractText | This study evaluated the activity of daptomycin combined with either gentamicin or rifampin against three methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates in vitro and one isolate in vivo against a representative strain (MRSA-572). Time-kill experiments showed that daptomycin was bactericidal against these strains at concentrations over the MIC. Daptomycin at sub-MIC concentrations plus gentamicin at 1x and 2x the MIC yielded synergy, while the addition of rifampin at 2 to 4 microg/ml resulted in indifference (two strains) or antagonism (one strain). The in vivo activity of daptomycin (6 mg/kg of body weight once a day) was evaluated +/- gentamicin (1 mg/kg intravenously [i.v.] every 8 h [q8h]) or rifampin (300 mg i.v. q8h) in a rabbit model of infective endocarditis by simulating human pharmacokinetics. Daptomycin plus gentamicin (median, 0 [interquartile range, 0 to 2] log10 CFU/g vegetation) was as effective as daptomycin alone (0 [0 to 2] log10 CFU/g vegetation) in reducing the density of bacteria in valve vegetations (P = 0.83), and both were more effective than daptomycin plus rifampin (3 [2 to 3.5] log10 CFU/g vegetation; P < 0.05) for the strain studied. In addition, daptomycin sterilized a ratio of vegetations that was similar to that of daptomycin plus gentamicin (10/15 [67%] versus 9/15 [60%]; P = 0.7), and both regimens did so more than daptomycin plus rifampin (3/15 [20%]; P = 0.01 and P = 0.02, respectively). No statistical difference was noted between daptomycin plus gentamicin and daptomycin alone for MRSA treatment. In the combination arm, all isolates from vegetations remained susceptible to daptomycin, gentamicin, and rifampin. Sixty-one percent of the isolates (8/13) acquired resistance to rifampin during monotherapy. In the daptomycin arm, resistance was detected in only one case, in which the daptomycin MIC rose to 2 microg/ml among the recovered bacteria. In conclusion, the addition of gentamicin or rifampin does not enhance the effectiveness of daptomycin in the treatment of experimental endocarditis due to MRSA. | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19620326 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19620326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19620326 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19620326 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19620326 | pubmed:issn | 1098-6596 | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:MorenoAA | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:del RíoAA | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:GatellJ MJM | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:Jiménez de... | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:MarcoFF | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:MestresC ACA | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:MiróJ MJM | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:AlmelaMM | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:SonKK | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:SarasaMM | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:Hospital... | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:García-de-la-... | lld:pubmed |
| pubmed-article:19620326 | pubmed:author | pubmed-author:ArmeroYY | lld:pubmed |
| pubmed-article:19620326 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19620326 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:19620326 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19620326 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19620326 | pubmed:pagination | 4172-7 | lld:pubmed |
| pubmed-article:19620326 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
| pubmed-article:19620326 | pubmed:meshHeading | pubmed-meshheading:19620326... | lld:pubmed |
| pubmed-article:19620326 | pubmed:meshHeading | pubmed-meshheading:19620326... | lld:pubmed |
| pubmed-article:19620326 | pubmed:meshHeading | pubmed-meshheading:19620326... | lld:pubmed |
| pubmed-article:19620326 | pubmed:meshHeading | pubmed-meshheading:19620326... | lld:pubmed |
| pubmed-article:19620326 | pubmed:meshHeading | pubmed-meshheading:19620326... | lld:pubmed |
| pubmed-article:19620326 | pubmed:meshHeading | pubmed-meshheading:19620326... | lld:pubmed |
| pubmed-article:19620326 | pubmed:meshHeading | pubmed-meshheading:19620326... | lld:pubmed |
| pubmed-article:19620326 | pubmed:meshHeading | pubmed-meshheading:19620326... | lld:pubmed |
| pubmed-article:19620326 | pubmed:meshHeading | pubmed-meshheading:19620326... | lld:pubmed |
| pubmed-article:19620326 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19620326 | pubmed:articleTitle | Addition of gentamicin or rifampin does not enhance the effectiveness of daptomycin in treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. | lld:pubmed |
| pubmed-article:19620326 | pubmed:affiliation | Infectious Diseases Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain. jmmiro@ub.edu | lld:pubmed |
| pubmed-article:19620326 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19620326 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19620326 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19620326 | lld:pubmed |
