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pubmed-article:19606947pubmed:abstractTextAlginate microspheres loaded with dexamethasone were prepared by the droplet generator technique. Important parameters affecting drug release, including initial drug content, the type of polyelectrolyte coating, and a combination of different ratios of coated and uncoated microspheres were investigated to achieve in vitro dexamethasone delivery with approximately zero order release kinetics, releasing up to 100% of entrapped drug within 1 month, wherein dexamethasone released at a steady rate of 4.83 microg/day after an initial burst release period. These findings imply that these polyelectrolyte-coated alginate microspheres show promise as release systems to improve biocompatibility and prolong lifetime of implantable glucose sensors.lld:pubmed
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pubmed-article:19606947pubmed:authorpubmed-author:SrivastavaRRlld:pubmed
pubmed-article:19606947pubmed:authorpubmed-author:McShaneM JMJlld:pubmed
pubmed-article:19606947pubmed:authorpubmed-author:JayantR DRDlld:pubmed
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pubmed-article:19606947pubmed:volume16lld:pubmed
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pubmed-article:19606947pubmed:pagination331-40lld:pubmed
pubmed-article:19606947pubmed:dateRevised2011-9-22lld:pubmed
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pubmed-article:19606947pubmed:articleTitlePolyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release.lld:pubmed
pubmed-article:19606947pubmed:affiliationSchool of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai, India.lld:pubmed
pubmed-article:19606947pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19606947pubmed:publicationTypeComparative Studylld:pubmed
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