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19565248

Source:http://linkedlifedata.com/resource/pubmed/id/19565248

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pubmed-article:19565248pubmed:dateCreated2009-10-16lld:pubmed
pubmed-article:19565248pubmed:abstractTextThe colon of the brushtail possum does not have an electrogenic secretory response. Given the functional significance of electrogenic Cl(-) secretion in the intestine of eutherian mammals, we have investigated the secretory response in the small intestine of this marsupial. In the Ussing chamber cAMP-dependent secretagogues stimulated a sustained increase in ileal short-circuit current (Isc), whereas Ca(2+)-dependent secretagogues induced a transient increase. Both the responses were inhibited by mucosal addition of the anion channel blocker 5-nitro-2-(3-phenylpropylamino) benzoic acid (100 mciromol l(-1)), consistent with an anion secretory response. However, the responses were not inhibited by serosal bumetanide (10 mciromol l(-1)) and were independent of bath Cl(-), indicating that the stimulated ileal Isc does not involve electrogenic Cl(-) secretion driven by the NaK2Cl cotransporter, NKCC1. Consistent with this, there were low levels of NKCC1 expression in the ileal epithelium. In particular, NKCC1 expression in the ileal crypt cells was comparable to that of the villous cells. This differs from eutherian mammals where high levels of NKCC1 expression in the ileal crypt cells are associated with their role in Cl(-) secretion. The cAMP- and Ca(2+)-dependent secretory responses were inhibited by the removal of HCO(3) (-) suggesting that these responses were due to electrogenic HCO(3) (-) secretion. We conclude that the ileum of the possum does not secrete Cl(-) due to low levels of NKCC1 expression. It does however appear to secrete HCO(3) (-). These results are further significant examples of differences in the transport function of the possum intestinal epithelium compared with eutherian mammals.lld:pubmed
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pubmed-article:19565248pubmed:year2009lld:pubmed
pubmed-article:19565248pubmed:articleTitleElectrogenic Cl(-) secretion does not occur in the ileum of the Australian common brushtail possum, Trichosurus vulpecula, due to low levels of expression of the NaK2Cl cotransporter, NKCC1.lld:pubmed
pubmed-article:19565248pubmed:affiliationInvermay Agricultural Centre, AgResearch, Private Bag 50034, Mosgiel, 9024, New Zealand.lld:pubmed
pubmed-article:19565248pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:19565248pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed