The FOXG1 gene has been recently implicated in the congenital form of Rett syndrome (RTT). It encodes the fork-head box protein G1, a winged-helix transcriptional repressor with expression restricted to testis and brain, where it is critical for forebrain development. So far, only two point mutations in FOXG1 have been reported in females affected by the congenital form of RTT. Aim To assess the involvement of FOXG1 in the molecular aetiology of classical RTT and related disorders.
Laboratoire de Génétique Médicale, Nancy Université, EA 4002, Centre Hospitalier Régional et Universitaire, 54511 cedex 1, Vandoeuvre-les-Nancy, France. c.philippe@chu-nancy.fr
