| pubmed-article:19559670 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19559670 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:19559670 | lifeskim:mentions | umls-concept:C0036226 | lld:lifeskim |
| pubmed-article:19559670 | lifeskim:mentions | umls-concept:C0206146 | lld:lifeskim |
| pubmed-article:19559670 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:19559670 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:19559670 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:19559670 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19559670 | pubmed:dateCreated | 2009-7-31 | lld:pubmed |
| pubmed-article:19559670 | pubmed:abstractText | Myocardial stunning (temporary post-ischaemic contractile dysfunction) may be caused by oxidative stress and/or impaired myocyte calcium homeostasis. Regional myocardial stunning was induced in open-chest pigs (segment shortening reduced to 68.3+/-4.7% of baseline) by repetitive brief circumflex coronary occlusion (I/R). Reduced glutathione was depleted in stunned myocardium (1.34+/-0.06 vs. 1.77+/-0.11 nmol/mg, p=0.02 vs. remote myocardium) indicating regional oxidant stress, but no regional differences were observed in protein-bound 3-nitrotyrosine or S-nitrosothiol content. Repetitive I/R did not affect myocardial quantities of the sarcolemmal sodium-calcium exchanger, L-type channel, SR calcium ATPase and phospholamban, or the kinetics of ligand binding to L-type channels and SR calcium release channels. However, initial rates of oxalate-supported (45)Ca uptake by SR were impaired in stunned myocardium (41.3+/-13.5 vs. 73.0+/-15.6 nmol/min/mg protein, p=0.03). The ability of SR calcium ATPase to sequester cytosolic calcium is impaired in stunned myocardium. This is a potential mechanism underlying contractile dysfunction. | lld:pubmed |
| pubmed-article:19559670 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19559670 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19559670 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19559670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19559670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19559670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19559670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19559670 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19559670 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19559670 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:19559670 | pubmed:author | pubmed-author:KumarSanjayS | lld:pubmed |
| pubmed-article:19559670 | pubmed:author | pubmed-author:RimoldiOrnell... | lld:pubmed |
| pubmed-article:19559670 | pubmed:author | pubmed-author:CamiciPaolo... | lld:pubmed |
| pubmed-article:19559670 | pubmed:author | pubmed-author:HallRoger J... | lld:pubmed |
| pubmed-article:19559670 | pubmed:author | pubmed-author:WilliamsAlan... | lld:pubmed |
| pubmed-article:19559670 | pubmed:author | pubmed-author:MooreKevin... | lld:pubmed |
| pubmed-article:19559670 | pubmed:author | pubmed-author:ManiAli RAR | lld:pubmed |
| pubmed-article:19559670 | pubmed:author | pubmed-author:MacleodKennet... | lld:pubmed |
| pubmed-article:19559670 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19559670 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:19559670 | pubmed:volume | 387 | lld:pubmed |
| pubmed-article:19559670 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19559670 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19559670 | pubmed:pagination | 77-82 | lld:pubmed |
| pubmed-article:19559670 | pubmed:meshHeading | pubmed-meshheading:19559670... | lld:pubmed |
| pubmed-article:19559670 | pubmed:meshHeading | pubmed-meshheading:19559670... | lld:pubmed |
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| pubmed-article:19559670 | pubmed:meshHeading | pubmed-meshheading:19559670... | lld:pubmed |
| pubmed-article:19559670 | pubmed:meshHeading | pubmed-meshheading:19559670... | lld:pubmed |
| pubmed-article:19559670 | pubmed:meshHeading | pubmed-meshheading:19559670... | lld:pubmed |
| pubmed-article:19559670 | pubmed:meshHeading | pubmed-meshheading:19559670... | lld:pubmed |
| pubmed-article:19559670 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19559670 | pubmed:articleTitle | Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum. | lld:pubmed |
| pubmed-article:19559670 | pubmed:affiliation | National Heart & Lung Institute, Imperial College, London, UK. S.Kumar3@rbht.nhs.uk | lld:pubmed |
| pubmed-article:19559670 | pubmed:publicationType | Journal Article | lld:pubmed |
