| pubmed-article:19541843 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19541843 | lifeskim:mentions | umls-concept:C0025611 | lld:lifeskim |
| pubmed-article:19541843 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19541843 | lifeskim:mentions | umls-concept:C0231921 | lld:lifeskim |
| pubmed-article:19541843 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:19541843 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:19541843 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19541843 | pubmed:dateCreated | 2010-4-15 | lld:pubmed |
| pubmed-article:19541843 | pubmed:abstractText | Although use of methamphetamine (MA) by smoking is the fastest growing method of administration, very limited data are available describing the effects of smoked MA. Using a murine inhalation exposure system, we explored the pulmonary effects of low-dose acute inhalation exposure to MA vapor (smoke). Inhalation of MA vapor resulted in transiently reduced pulmonary function, as measured by transpulmonary resistance, dynamic compliance, and whole-body plethysmography compared with unexposed control animals. These changes were associated with an approximately 34% reduction in serotonin (5-hydroxytryptamine [5-HT]) metabolism/inactivation to 5-hydroxyindolacetic acid, and a nearly 40% reduction in monoamine oxidase (MAO)-A activity in the lung. Pretreatment of mice with a selective 5-HT reuptake inhibitor completely ablated the MA-induced changes in pulmonary function, confirming a key role for the 5-HT transporter (serotonin transporter [SERT]) and the serotonergic system in this effect. Immunofluorescent staining of mouse lung tissue confirmed high expression of SERT in airway epithelial cells. Using mouse airway epithelial cell line, LA-4, and purified human MAO-A, it was demonstrated that MA impedes 5-HT metabolism through direct inhibition of MAO-A activity in vitro. Together, these data demonstrate that low-dose exposure to MA results in reduced pulmonary function mediated via SERT and subsequent perturbation of 5-HT metabolism in the lung. This supports a role for the serotonergic system in MA-mediated pulmonary effects. | lld:pubmed |
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| pubmed-article:19541843 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19541843 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19541843 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19541843 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19541843 | pubmed:month | May | lld:pubmed |
| pubmed-article:19541843 | pubmed:issn | 1535-4989 | lld:pubmed |
| pubmed-article:19541843 | pubmed:author | pubmed-author:Cardozo-Pelae... | lld:pubmed |
| pubmed-article:19541843 | pubmed:author | pubmed-author:HolianAndrijA | lld:pubmed |
| pubmed-article:19541843 | pubmed:author | pubmed-author:WellsSandra... | lld:pubmed |
| pubmed-article:19541843 | pubmed:author | pubmed-author:BufordMary... | lld:pubmed |
| pubmed-article:19541843 | pubmed:author | pubmed-author:Bunderson-Sch... | lld:pubmed |
| pubmed-article:19541843 | pubmed:author | pubmed-author:PorterVirgini... | lld:pubmed |
| pubmed-article:19541843 | pubmed:author | pubmed-author:BrunellHeathe... | lld:pubmed |
| pubmed-article:19541843 | pubmed:author | pubmed-author:NevinAndrew... | lld:pubmed |
| pubmed-article:19541843 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19541843 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:19541843 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19541843 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19541843 | pubmed:pagination | 537-44 | lld:pubmed |
| pubmed-article:19541843 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:19541843 | pubmed:meshHeading | pubmed-meshheading:19541843... | lld:pubmed |
| pubmed-article:19541843 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19541843 | pubmed:articleTitle | Role of the serotonergic system in reduced pulmonary function after exposure to methamphetamine. | lld:pubmed |
| pubmed-article:19541843 | pubmed:affiliation | Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska 68198-5910, USA. smwells@unmc.edu | lld:pubmed |
| pubmed-article:19541843 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19541843 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:19541843 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
