| pubmed-article:19525941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19525941 | lifeskim:mentions | umls-concept:C0085139 | lld:lifeskim |
| pubmed-article:19525941 | lifeskim:mentions | umls-concept:C1415504 | lld:lifeskim |
| pubmed-article:19525941 | lifeskim:mentions | umls-concept:C1334478 | lld:lifeskim |
| pubmed-article:19525941 | lifeskim:mentions | umls-concept:C0598954 | lld:lifeskim |
| pubmed-article:19525941 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:19525941 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19525941 | pubmed:dateCreated | 2009-6-25 | lld:pubmed |
| pubmed-article:19525941 | pubmed:abstractText | Selected vulnerability of neurons in Huntington's disease suggests that alterations occur in a cellular process that is particularly critical for neuronal function. Supporting this idea, pathogenic Htt (polyQ-Htt) inhibits fast axonal transport (FAT) in various cellular and animal models of Huntington's disease (mouse and squid), but the molecular basis of this effect remains unknown. We found that polyQ-Htt inhibited FAT through a mechanism involving activation of axonal cJun N-terminal kinase (JNK). Accordingly, we observed increased activation of JNK in vivo in cellular and mouse models of Huntington's disease. Additional experiments indicated that the effects of polyQ-Htt on FAT were mediated by neuron-specific JNK3 and not by ubiquitously expressed JNK1, providing a molecular basis for neuron-specific pathology in Huntington's disease. Mass spectrometry identified a residue in the kinesin-1 motor domain that was phosphorylated by JNK3 and this modification reduced kinesin-1 binding to microtubules. These data identify JNK3 as a critical mediator of polyQ-Htt toxicity and provide a molecular basis for polyQ-Htt-induced inhibition of FAT. | lld:pubmed |
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| pubmed-article:19525941 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19525941 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19525941 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19525941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19525941 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19525941 | pubmed:issn | 1546-1726 | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:BradyScott... | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:HuangChun-Fan... | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:PiginoGustavo... | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:CoffeyEleanor... | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:BjörkblomBenn... | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:YoshiokaKatsu... | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:BankerGaryG | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:MorfiniGerard... | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:BagnatoCaroli... | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:DobayAkosA | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:KaminskaAgnie... | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:LiuKatherineK | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:YouYi-MeiYM | lld:pubmed |
| pubmed-article:19525941 | pubmed:author | pubmed-author:PollemaSarah... | lld:pubmed |
| pubmed-article:19525941 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19525941 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:19525941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19525941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19525941 | pubmed:pagination | 864-71 | lld:pubmed |
