Linked Life Data

19506000

Source:http://linkedlifedata.com/resource/pubmed/id/19506000

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pubmed-article:19506000pubmed:dateCreated2009-8-14lld:pubmed
pubmed-article:19506000pubmed:abstractTextDisease response genes (DRGs) diverge under recurrent positive selection as a result of a molecular arms race between hosts and pathogens. Most of these studies were conducted in animals, and few defense genes have been shown to evolve adaptively in plants. To test for adaptation in the molecules mediating disease resistance in the cereals, we first combined information from the expression pattern of Sorghum bicolor genes and from divergence to the full genome of rice to identify candidate DRGs. We then used evolutionary analyses of orthologous gene sets from several grass species, to determine whether the DRGs show signals of positive selection and the residues targeted. We found 140 divergent genes upregulated under biotic stress in S. bicolor by evaluating the relative abundance of expressed sequence tags in different libraries and comparing them with rice genes. For 10 of these genes, we found sets of orthologs including sequences from rice and three other cereals; six genes showed a pattern of substitution that was consistent with positive selection. Three of these genes, a thaumatin, a peroxidase, and a barley mlo homolog, are known antifungal proteins. The other three genes with evidence of positive selection were a MCM-1 agamous deficiens SRF- (MADS) box transcription factor, an eIF5 translation initiation factor, and a gene of unknown function but with evidence of expression during stress. Permutation analyses, using different ortholog and paralog sequences, consistently identified five positively selected codons in the peroxidase, a member of a cluster of genes and a large gene family. We mapped the positively selected residues onto the structure of the peroxidase and thaumatin and found that all sites are on the surface of these proteins and several are close to biochemically determined active sites. Identifying new positively selected plant disease resistance genes and the critical amino acid sites provides a basis for functional studies that may increase our understanding of their underlying molecular mechanisms of action. Additionally, it may lead to the identification of individuals having variation at functionally important sites, as well as eventually using this information in the rational design and engineering of proteins involved in plant disease resistance.lld:pubmed
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pubmed-article:19506000pubmed:pagination2015-30lld:pubmed
pubmed-article:19506000pubmed:dateRevised2010-9-2lld:pubmed
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pubmed-article:19506000pubmed:year2009lld:pubmed
pubmed-article:19506000pubmed:articleTitlePositively selected disease response orthologous gene sets in the cereals identified using Sorghum bicolor L. Moench expression profiles and comparative genomics.lld:pubmed
pubmed-article:19506000pubmed:affiliationInstitute for Genomic Diversity, Cornell University, Ithaca, NY, USA. az42@cornell.edulld:pubmed
pubmed-article:19506000pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19506000pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:19506000pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:19506000pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed