| pubmed-article:19500679 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19500679 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:19500679 | lifeskim:mentions | umls-concept:C0031001 | lld:lifeskim |
| pubmed-article:19500679 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:19500679 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:19500679 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:19500679 | lifeskim:mentions | umls-concept:C1135159 | lld:lifeskim |
| pubmed-article:19500679 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19500679 | pubmed:dateCreated | 2009-8-11 | lld:pubmed |
| pubmed-article:19500679 | pubmed:abstractText | Levels of extra-synaptic dopamine in the brain vary as a function of polymorphisms at the val158met locus of the catechol-O-methyltransferase (COMT) gene. In vivo studies of this polymorphism in the human brain have typically measured patterns of neural activation during dopamine-mediated tasks in adults. This study is the first to investigate the effects of COMT on brain physiology during rest and in children. We used flow-sensitive arterial spin-labeling (ASL) magnetic resonance imaging to examine brain blood flow (CBF) in 42 children. Compared with val-allele carriers, met-allele homozygotes exhibited greater CBF in mesolimbic, mesocortical, and nigrostriatal dopamine (DA) pathways. Higher CBF in DA-rich brain structures reflects COMT-related baseline differences that (1) underlie the selective behavioral advantages associated with each genotype; (2) affect interpretations of previously reported genotype differences in BOLD signal changes; and (3) serve as a foundation for future studies on the effects of COMT on brain development. | lld:pubmed |
| pubmed-article:19500679 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19500679 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19500679 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19500679 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19500679 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19500679 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19500679 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19500679 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19500679 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19500679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19500679 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19500679 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19500679 | pubmed:issn | 1095-9572 | lld:pubmed |
| pubmed-article:19500679 | pubmed:author | pubmed-author:GloverGary... | lld:pubmed |
| pubmed-article:19500679 | pubmed:author | pubmed-author:ThomasonMoria... | lld:pubmed |
| pubmed-article:19500679 | pubmed:author | pubmed-author:GotlibIan HIH | lld:pubmed |
| pubmed-article:19500679 | pubmed:author | pubmed-author:WaughChristia... | lld:pubmed |
| pubmed-article:19500679 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19500679 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19500679 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:19500679 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19500679 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19500679 | pubmed:pagination | 217-22 | lld:pubmed |
| pubmed-article:19500679 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:meshHeading | pubmed-meshheading:19500679... | lld:pubmed |
| pubmed-article:19500679 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19500679 | pubmed:articleTitle | COMT genotype and resting brain perfusion in children. | lld:pubmed |
| pubmed-article:19500679 | pubmed:affiliation | Department of Psychology, Stanford University, Stanford, CA 94305-2130, USA. moriah@stanford.edu | lld:pubmed |
| pubmed-article:19500679 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19500679 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19500679 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:1312 | entrezgene:pubmed | pubmed-article:19500679 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19500679 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19500679 | lld:entrezgene |
