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pubmed-article:19495517pubmed:abstractTextAmikacin is a commonly-prescribed drug used for the empirical treatment of bacterial infections in neonates. A marked change in the pharmacokinetics of amikacin has been reported during neonatal life. Amikacin has a very narrow therapeutic range and can cause very serious side effects such as nephrotoxicity and ototoxicity. The current therapeutic dose of amikacin, i.e. 15 mg/kg of body weight, may increase the risk of toxicity in preterm infants with immature renal functions. We aimed to determine the frequency of amikacin toxicity in preterm as compared to term infants by measuring its serum trough levels following the administration of the current therapeutic dose.lld:pubmed
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pubmed-article:19495517pubmed:year2009lld:pubmed
pubmed-article:19495517pubmed:articleTitleTherapeutic drug monitoring of amikacin in preterm and term infants.lld:pubmed
pubmed-article:19495517pubmed:affiliationDepartment of Pathology, Army Medical College, National University of Sciences and Technology, Abid Majeed Road, Rawalpindi, Pakistan.lld:pubmed
pubmed-article:19495517pubmed:publicationTypeJournal Articlelld:pubmed
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