| pubmed-article:19479085 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C0333051 | lld:lifeskim |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C1332700 | lld:lifeskim |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C2936624 | lld:lifeskim |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:19479085 | lifeskim:mentions | umls-concept:C0870509 | lld:lifeskim |
| pubmed-article:19479085 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19479085 | pubmed:dateCreated | 2009-5-29 | lld:pubmed |
| pubmed-article:19479085 | pubmed:abstractText | High-throughput sequencing platforms provide an approach for detecting rare HIV-1 variants and documenting more fully quasispecies diversity. We applied this technology to the V3 loop-coding region of env in samples collected from 4 chronically HIV-infected subjects in whom CCR5 antagonist (vicriviroc [VVC]) therapy failed. Between 25,000-140,000 amplified sequences were obtained per sample. Profound baseline V3 loop sequence heterogeneity existed; predicted CXCR4-using populations were identified in a largely CCR5-using population. The V3 loop forms associated with subsequent virologic failure, either through CXCR4 use or the emergence of high-level VVC resistance, were present as minor variants at 0.8-2.8% of baseline samples. Extreme, rapid shifts in population frequencies toward these forms occurred, and deep sequencing provided a detailed view of the rapid evolutionary impact of VVC selection. Greater V3 diversity was observed post-selection. This previously unreported degree of V3 loop sequence diversity has implications for viral pathogenesis, vaccine design, and the optimal use of HIV-1 CCR5 antagonists. | lld:pubmed |
| pubmed-article:19479085 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19479085 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19479085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19479085 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19479085 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:ParedesRogerR | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:GulickRoy MRM | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:NusbaumChadC | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:KorberBetteB | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:RussCarstenC | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:HughesMichael... | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:FlexnerCharle... | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:LeitnerThomas... | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:GaschenBrianB | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:KuritzkesDani... | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:TheilerJamesJ | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:CoakleyEoinE | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:GreavesWayneW | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:SuZhaohuiZ | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:TsibrisAthe... | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:ArnaoutRamyR | lld:pubmed |
| pubmed-article:19479085 | pubmed:author | pubmed-author:LoChien-ChiCC | lld:pubmed |
| pubmed-article:19479085 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19479085 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:19479085 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19479085 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19479085 | pubmed:pagination | e5683 | lld:pubmed |
| pubmed-article:19479085 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
| pubmed-article:19479085 | pubmed:meshHeading | pubmed-meshheading:19479085... | lld:pubmed |
