| pubmed-article:19473882 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C0151317 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C0400914 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C1412933 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:19473882 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:19473882 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19473882 | pubmed:dateCreated | 2009-8-3 | lld:pubmed |
| pubmed-article:19473882 | pubmed:abstractText | CD4+ T cell responses are impaired in chronic HCV infection. To determine factor(s) involved in CD4+ T cell dysregulation, we examined the effect of extracellular core on the alteration of CD4+ T cell responses and the cell surface level of core-binding protein, gC1qR on CD4+ T cells from acute HCV patients with resolved and chronic infection. During the acute phase of infection, the frequency of gC1qR+CD4+ T cells increased in both resolved and chronic HCV infection compared to healthy controls. Notably, 6 months later, the frequency of gC1qR+CD4+ T cells maintained elevated in chronic patients compared to that in resolved patients. In addition, TCR stimulation increased the frequency of gC1qR+CD4+ T cells, resulting in core-induced inhibition of T cell responses in both resolved and chronic patients. These results suggest that HCV infection expands gC1qR+CD4+ T cells, which increase the susceptibility to core-mediated immune dysregulation and facilitate the establishment of HCV persistency. | lld:pubmed |
| pubmed-article:19473882 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19473882 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19473882 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19473882 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19473882 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19473882 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19473882 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19473882 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19473882 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19473882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19473882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19473882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19473882 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19473882 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19473882 | pubmed:issn | 1521-7035 | lld:pubmed |
| pubmed-article:19473882 | pubmed:author | pubmed-author:RosenHugo RHR | lld:pubmed |
| pubmed-article:19473882 | pubmed:author | pubmed-author:HahnYoung SYS | lld:pubmed |
| pubmed-article:19473882 | pubmed:author | pubmed-author:CummingsKara... | lld:pubmed |
| pubmed-article:19473882 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19473882 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:19473882 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19473882 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19473882 | pubmed:pagination | 401-11 | lld:pubmed |
| pubmed-article:19473882 | pubmed:dateRevised | 2011-1-24 | lld:pubmed |
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| pubmed-article:19473882 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19473882 | pubmed:articleTitle | Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection. | lld:pubmed |
| pubmed-article:19473882 | pubmed:affiliation | Beirne Carter Center for Immunology Research and Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA. | lld:pubmed |
| pubmed-article:19473882 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19473882 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:708 | entrezgene:pubmed | pubmed-article:19473882 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19473882 | lld:entrezgene |
