| pubmed-article:19460867 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19460867 | lifeskim:mentions | umls-concept:C1309483 | lld:lifeskim |
| pubmed-article:19460867 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:19460867 | lifeskim:mentions | umls-concept:C1622209 | lld:lifeskim |
| pubmed-article:19460867 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:19460867 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:19460867 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:19460867 | lifeskim:mentions | umls-concept:C1333218 | lld:lifeskim |
| pubmed-article:19460867 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:19460867 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:19460867 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19460867 | pubmed:dateCreated | 2009-6-22 | lld:pubmed |
| pubmed-article:19460867 | pubmed:abstractText | Small RNAs play important roles in the establishment and maintenance of heterochromatin structures. We show the presence of telomere specific small RNAs (tel-sRNAs) in mouse embryonic stem cells that are approximately 24 nucleotides in length, Dicer-independent, and 2'-O-methylated at the 3' terminus. The tel-sRNAs are asymmetric with specificity toward telomere G-rich strand, and evolutionarily conserved from protozoan to mammalian cells. Furthermore, tel-sRNAs are up-regulated in cells that carry null mutation of H3K4 methyltransferase MLL (Mll((-/-))) and down-regulated in cells that carry null mutations of histone H3K9 methyltransferase SUV39H (Suv39h1/h2((-/-))), suggesting that they are subject to epigenetic regulation. These results support that tel-sRNAs are heterochromatin associated pi-like small RNAs. | lld:pubmed |
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| pubmed-article:19460867 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19460867 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19460867 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19460867 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19460867 | pubmed:issn | 1469-9001 | lld:pubmed |
| pubmed-article:19460867 | pubmed:author | pubmed-author:DouYaliY | lld:pubmed |
| pubmed-article:19460867 | pubmed:author | pubmed-author:LiuYifanY | lld:pubmed |
| pubmed-article:19460867 | pubmed:author | pubmed-author:BradyHughH | lld:pubmed |
| pubmed-article:19460867 | pubmed:author | pubmed-author:CaoFangF | lld:pubmed |
| pubmed-article:19460867 | pubmed:author | pubmed-author:LiXiangzhiX | lld:pubmed |
| pubmed-article:19460867 | pubmed:author | pubmed-author:HiewSamanthaS | lld:pubmed |
| pubmed-article:19460867 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19460867 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:19460867 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19460867 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19460867 | pubmed:pagination | 1274-81 | lld:pubmed |
| pubmed-article:19460867 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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