| pubmed-article:1944605 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1944605 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:1944605 | lifeskim:mentions | umls-concept:C0030352 | lld:lifeskim |
| pubmed-article:1944605 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:1944605 | lifeskim:mentions | umls-concept:C0003289 | lld:lifeskim |
| pubmed-article:1944605 | lifeskim:mentions | umls-concept:C1710637 | lld:lifeskim |
| pubmed-article:1944605 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1944605 | lifeskim:mentions | umls-concept:C0131796 | lld:lifeskim |
| pubmed-article:1944605 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1944605 | pubmed:dateCreated | 1991-12-13 | lld:pubmed |
| pubmed-article:1944605 | pubmed:abstractText | The effects of (S)-nafenodone, a new antidepressant, on transmembrane action potentials were studied in guinea-pig papillary muscles. In muscles driven at 0.02 and 1 Hz, (S)-nafenodone, 10(-6) mol/l and 10(-5) mol/l, produced a concentration-dependent decrease in the maximum upstroke velocity of the action potential, but it had no effect of the resting membrane potential. In the presence of 10(-5) mol/l (S)-nafenodone, trains of stimuli at rates between 0.5 and 2 Hz led to an exponential decline in maximum upstroke velocity to a new steady-state level [K = 0.152 +/- 0.03 (action potential)-1 at 2 Hz]. This frequency-dependent maximum upstroke velocity block increased at higher stimulation frequencies and at higher drug concentrations. (S)-Nafenodone also prolonged the time constant of recovery of maximum upstroke velocity from the frequency-dependent block to 2.3 +/- 0.6 s, this value being independent of the drug concentration. These values of onset and offset kinetics of (S)-nafenodone lie between those of drugs with fast and intermediate kinetic properties. (S)-nafenodone also shifted the curve relating membrane potential and maximum upstroke velocity in hyperpolarizing direction. All these results indicated that (S)-nafenodone produced a frequency- and voltage-dependent inhibition of the fast sodium channels similar to that exhibited with imipramine. | lld:pubmed |
| pubmed-article:1944605 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1944605 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1944605 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1944605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1944605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1944605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1944605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1944605 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1944605 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1944605 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:1944605 | pubmed:author | pubmed-author:TamargoJJ | lld:pubmed |
| pubmed-article:1944605 | pubmed:author | pubmed-author:ValenzuelaCC | lld:pubmed |
| pubmed-article:1944605 | pubmed:author | pubmed-author:DelpónEE | lld:pubmed |
| pubmed-article:1944605 | pubmed:author | pubmed-author:Pérez-Vizcain... | lld:pubmed |
| pubmed-article:1944605 | pubmed:author | pubmed-author:CarrónRR | lld:pubmed |
| pubmed-article:1944605 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1944605 | pubmed:volume | 343 | lld:pubmed |
| pubmed-article:1944605 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1944605 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1944605 | pubmed:pagination | 638-44 | lld:pubmed |
| pubmed-article:1944605 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:meshHeading | pubmed-meshheading:1944605-... | lld:pubmed |
| pubmed-article:1944605 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1944605 | pubmed:articleTitle | Tonic and frequency-dependent Vmax block induced by (S)-nafenodone, a new antidepressant drug, in guinea-pig papillary muscles. | lld:pubmed |
| pubmed-article:1944605 | pubmed:affiliation | Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain. | lld:pubmed |
| pubmed-article:1944605 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1944605 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
