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pubmed-article:19444268pubmed:abstractTextThe binding of Shiga-like toxins (Stx) to globotriaosyl ceramide (Gb(3)) in renal cells plays a central role in Stx-induced hemolytic uremic syndrome (Stx-HUS). Khan et al. show that the presence of Gb(3) within lipid raft microdomains in glomerular but not tubular cells may be the basis for the glomerular- and age-restricted pathology of Stx-HUS. They also propose that the binding of the HIV-1 glycoprotein gp120 to Gb(3) in renal tubules may play a role in HIV nephropathy.lld:pubmed
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pubmed-article:19444268pubmed:articleTitleShiga-like toxins and HIV-1 'go through' glycosphingolipids and lipid rafts in renal cells.lld:pubmed
pubmed-article:19444268pubmed:affiliationChildren's Research Institute, Children's National Medical Center, and Department of Pediatrics, The George Washington University, Washington, DC, USA. Pray@cnmc.orglld:pubmed
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