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pubmed-article:19427846pubmed:abstractTextA low folate/high homocysteine phenotype is associated with several pathologies, including spina bifida and cardiovascular disease. Folate and total homocysteine (tHcy) measurements are used clinically to assess risk and the need for folic acid supplementation and in research to investigate the metabolic basis of disease. Red blood cell (RBC) folate, the best indicator of long-term folate status, is usually measured as "total" folate. However, different folate derivatives support distinct biochemical functions, suggesting a need to develop more precise methods. This study was designed to evaluate a method based on stable isotope dilution liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS).lld:pubmed
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pubmed-article:19427846pubmed:articleTitleFolate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data.lld:pubmed
pubmed-article:19427846pubmed:affiliationInstitute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, USA.lld:pubmed
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