| pubmed-article:1939343 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1939343 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:1939343 | lifeskim:mentions | umls-concept:C0225369 | lld:lifeskim |
| pubmed-article:1939343 | lifeskim:mentions | umls-concept:C0597295 | lld:lifeskim |
| pubmed-article:1939343 | lifeskim:mentions | umls-concept:C1515406 | lld:lifeskim |
| pubmed-article:1939343 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:1939343 | lifeskim:mentions | umls-concept:C1979572 | lld:lifeskim |
| pubmed-article:1939343 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:1939343 | lifeskim:mentions | umls-concept:C1980044 | lld:lifeskim |
| pubmed-article:1939343 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1939343 | pubmed:dateCreated | 1991-12-2 | lld:pubmed |
| pubmed-article:1939343 | pubmed:abstractText | Rabbit articular chondrocytes were incubated with recombinant transforming-growth-factor-beta 1 (rhTGF-beta 1) and its effect on newly synthesized proteoglycan measured. rhTGF-beta 1 stimulated proteoglycan synthesis at a concentration as low as 5 ng/ml without further increases in radiosulfate incorporation up to 50 ng/ml. The quantitative increase in radiosulfate incorporation in rh-TGF-beta 1-treated chondrocytes was greater in the cell-associated culture compartment than in the medium compartment. rhTGF-beta 1 promoted an increased proteoglycan retention in the cell-associated compartment as evidenced by an increase in the t1/2 of retention from 8 h to 11 h. Specific enhanced synthesis of [35S]-methionine-labeled core proteins was seen in rh-TGF-beta 1-treated chondrocytes. rh-TGF-beta 1 increased the synthesis of the 2 core proteins derived from hydrodynamically large proteoglycans. They possessed apparent molecular weights of greater than 480 kD and 390 kD after 3-5% acrylamide gel electrophoresis. A compartmental analysis revealed that the cell-associated culture compartment contained only the larger of the 2 core proteins derived from large proteoglycans. Two other core proteins with apparent molecular weights 52 kD and 46 kD were also stimulated by rhTGF-beta 1. These results indicated that TGF-beta probably plays a significant role in stimulating proteoglycan core protein synthesis in articular chondrocytes and therefore may be an important growth factor in the restoration of cartilage extracellular matrix after injury. | lld:pubmed |
| pubmed-article:1939343 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1939343 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1939343 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1939343 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1939343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1939343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1939343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1939343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1939343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1939343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1939343 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1939343 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1939343 | pubmed:issn | 0021-9541 | lld:pubmed |
| pubmed-article:1939343 | pubmed:author | pubmed-author:MalemudC JCJ | lld:pubmed |
| pubmed-article:1939343 | pubmed:author | pubmed-author:PurchioA FAF | lld:pubmed |
| pubmed-article:1939343 | pubmed:author | pubmed-author:HeringT MTM | lld:pubmed |
| pubmed-article:1939343 | pubmed:author | pubmed-author:KilleenWW | lld:pubmed |
| pubmed-article:1939343 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1939343 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:1939343 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1939343 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1939343 | pubmed:pagination | 152-9 | lld:pubmed |
| pubmed-article:1939343 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1939343 | pubmed:meshHeading | pubmed-meshheading:1939343-... | lld:pubmed |
| pubmed-article:1939343 | pubmed:meshHeading | pubmed-meshheading:1939343-... | lld:pubmed |
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| pubmed-article:1939343 | pubmed:meshHeading | pubmed-meshheading:1939343-... | lld:pubmed |
| pubmed-article:1939343 | pubmed:meshHeading | pubmed-meshheading:1939343-... | lld:pubmed |
| pubmed-article:1939343 | pubmed:meshHeading | pubmed-meshheading:1939343-... | lld:pubmed |
| pubmed-article:1939343 | pubmed:meshHeading | pubmed-meshheading:1939343-... | lld:pubmed |
| pubmed-article:1939343 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1939343 | pubmed:articleTitle | Enhanced sulfated-proteoglycan core protein synthesis by incubation of rabbit chondrocytes with recombinant transforming growth factor-beta 1. | lld:pubmed |
| pubmed-article:1939343 | pubmed:affiliation | Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106. | lld:pubmed |
| pubmed-article:1939343 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1939343 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1939343 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1939343 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1939343 | lld:pubmed |
