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pubmed-article:19389830pubmed:abstractTextGlucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indicates that in fact, GLP-1 in each location plays a role in these functions. This review summarizes the evidence for involvement of peripheral and brain GLP-1 in food intake regulation and glucose homeostasis and proposes a model for the coordinated actions of GLP-1 at multiple sites.lld:pubmed
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pubmed-article:19389830pubmed:articleTitleMinireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis.lld:pubmed
pubmed-article:19389830pubmed:affiliationDepartment of Psychology, 1107 West Call Street, Florida State University, Tallahassee, Florida 32306-4301, USA. williams@psy.fsu.edulld:pubmed
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