| pubmed-article:19383239 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C0302592 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C0007137 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C0333873 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C0001271 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C1332710 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19383239 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19383239 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19383239 | pubmed:dateCreated | 2009-4-22 | lld:pubmed |
| pubmed-article:19383239 | pubmed:abstractText | This retrospective study investigated CD34, alpha-smooth muscle actin (alpha-SMA), and transforming growth factor-beta1 (TGF-beta1) expression in stromal cells of cervical intraepithelial neoplasias (CINs; n = 30), invasive cervical squamous cell carcinomas (SCCs; n = 38) and adjacent normal cervix. Normal cervix and CINs contained diffuse CD34-positive stromal cells but no alpha-SMA-positive myofibroblasts. In contrast, 34 of 38 SCCs were free of CD34-positive stromal cells and all contained alpha-SMA-positive stromal myofibroblasts; adjacent normal tissue contained CD34-positive stromal cells and no alpha-SMA-positive myofibroblasts. More intense TGF-beta1 expression was observed in SCC cells than in normal cervical epithelium or CINs. This study shows that the disappearance of CD34-positive stromal cells and appearance of alpha-SMA-positive stromal myofibroblasts may be associated with transformation of cervical CIN to SCC. These findings support the suggestion that over-production of TGF-beta1 in SCC cells is one potential mechanism mediating the transformation of stromal cells to myofibroblasts in cervical carcinogenesis. | lld:pubmed |
| pubmed-article:19383239 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19383239 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19383239 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19383239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19383239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19383239 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19383239 | pubmed:issn | 0300-0605 | lld:pubmed |
| pubmed-article:19383239 | pubmed:author | pubmed-author:HuangWW | lld:pubmed |
| pubmed-article:19383239 | pubmed:author | pubmed-author:LUEE | lld:pubmed |
| pubmed-article:19383239 | pubmed:author | pubmed-author:ZhouXX | lld:pubmed |
| pubmed-article:19383239 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19383239 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:19383239 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19383239 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19383239 | pubmed:pagination | 446-54 | lld:pubmed |
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| pubmed-article:19383239 | pubmed:meshHeading | pubmed-meshheading:19383239... | lld:pubmed |
| pubmed-article:19383239 | pubmed:articleTitle | Expression of CD34, alpha-smooth muscle actin and transforming growth factor-beta1 in squamous intraepithelial lesions and squamous cell carcinoma of the cervix. | lld:pubmed |
| pubmed-article:19383239 | pubmed:affiliation | Department of Pathology, Clinical School of Medical College of Nanjing University, Nanjing Jinling Hospital, Nanjing, China. | lld:pubmed |
| pubmed-article:19383239 | pubmed:publicationType | Journal Article | lld:pubmed |
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