| pubmed-article:1935800 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1935800 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:1935800 | lifeskim:mentions | umls-concept:C0040162 | lld:lifeskim |
| pubmed-article:1935800 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:1935800 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1935800 | lifeskim:mentions | umls-concept:C1384607 | lld:lifeskim |
| pubmed-article:1935800 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1935800 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1935800 | pubmed:dateCreated | 1991-12-2 | lld:pubmed |
| pubmed-article:1935800 | pubmed:abstractText | Food deprivation in laboratory rats induces profound changes in the neuroendocrine system. We have investigated the hypothalamic and pituitary responses of the hypothalamo-pituitary thyroid axis to 48-h food deprivation in Sprague-Dawley rats. Peripheral T3 and hypophysial portal TRH were measured by RIA, and TSH beta, PRL, and pro-TRH mRNA were measured using in situ hybridization histochemistry. Peripheral total T3 was greatly reduced in food-deprived rats. Hypothalamic portal blood TRH levels declined significantly with time in control animals. The initial level of TRH in the portal blood of food-deprived rats was significantly reduced compared to that in controls, but did not fall further with time. In situ hybridization histochemistry revealed significantly lower pro-TRH mRNA in the paraventricular nucleus of food-deprived animals, while pro-TRH mRNA in the reticular nucleus remained unaltered. Furthermore, in the anterior pituitary, TSH beta mRNA decreased significantly in food-deprived animals, while PRL mRNA was unaltered. We conclude that the reduction in circulating T3 after food deprivation appears to be due primarily to decreased hypothalamic TRH synthesis and release. | lld:pubmed |
| pubmed-article:1935800 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1935800 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1935800 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1935800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1935800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1935800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1935800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1935800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1935800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1935800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1935800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1935800 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1935800 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1935800 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:1935800 | pubmed:author | pubmed-author:LightmanS LSL | lld:pubmed |
| pubmed-article:1935800 | pubmed:author | pubmed-author:FosterO JOJ | lld:pubmed |
| pubmed-article:1935800 | pubmed:author | pubmed-author:EcklandD JDJ | lld:pubmed |
| pubmed-article:1935800 | pubmed:author | pubmed-author:BlakeN GNG | lld:pubmed |
| pubmed-article:1935800 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1935800 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:1935800 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1935800 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1935800 | pubmed:pagination | 2714-8 | lld:pubmed |
| pubmed-article:1935800 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:meshHeading | pubmed-meshheading:1935800-... | lld:pubmed |
| pubmed-article:1935800 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1935800 | pubmed:articleTitle | Inhibition of hypothalamic thyrotropin-releasing hormone messenger ribonucleic acid during food deprivation. | lld:pubmed |
| pubmed-article:1935800 | pubmed:affiliation | Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom. | lld:pubmed |
| pubmed-article:1935800 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1935800 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1935800 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1935800 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1935800 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1935800 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1935800 | lld:pubmed |
