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pubmed-article:19338047pubmed:dateCreated2009-5-4lld:pubmed
pubmed-article:19338047pubmed:abstractTextThe t(7;11)(p15;p15) translocation has been reported as a rare and recurrent chromosomal abnormality in acute myeloid leukemia (AML) patients. The NUP98-HOXA9 fusion gene with t(7;11)(p15;p15) was identified and revealed to be essential for leukemogenesis and myeloproliferative disease. To date, t(7;11)(p15;p15) with NUP98-HOXA11 fusion has been reported only in one case of ph-negative chronic myeloid leukemia (CML). Here, we report a case of a 3-year-old girl with juvenile myelomonocytic leukemia (JMML) carrying t(7;11)(p15;p15) abnormality with NUP98-HOXA11 fusion. AML chemotherapy followed by bone marrow transplantation (BMT) was found to be effective in treating this disorder, and she remains in complete remission for 3 years after BMT. We suggest the possibility that AML chemotherapy might be effective for treating JMML with t(7;11)(p15;p15) abnormality and NUP98-HOXA11 fusion.lld:pubmed
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pubmed-article:19338047pubmed:authorpubmed-author:HamamotoKazuk...lld:pubmed
pubmed-article:19338047pubmed:authorpubmed-author:TakiTomohikoTlld:pubmed
pubmed-article:19338047pubmed:authorpubmed-author:HayashiYasuhi...lld:pubmed
pubmed-article:19338047pubmed:authorpubmed-author:FujitaNaotoNlld:pubmed
pubmed-article:19338047pubmed:authorpubmed-author:MizoguchiYoko...lld:pubmed
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pubmed-article:19338047pubmed:year2009lld:pubmed
pubmed-article:19338047pubmed:articleTitleJuvenile myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98-HOXA11 fusion.lld:pubmed
pubmed-article:19338047pubmed:affiliationDepartment of Pediatrics, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan. yoyotti129@yahoo.co.jplld:pubmed
pubmed-article:19338047pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19338047pubmed:publicationTypeCase Reportslld:pubmed