| pubmed-article:19304752 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C1956267 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:19304752 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:19304752 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:19304752 | pubmed:dateCreated | 2009-5-22 | lld:pubmed |
| pubmed-article:19304752 | pubmed:abstractText | Genetically programmed cell deaths play important roles in unicellular prokaryotes. In postsegregational killing, loss of a gene complex from a cell leads to its descendants' deaths. With type II restriction-modification gene complexes, such death is triggered by restriction endonuclease's attacks on under-methylated chromosomes. Here, we examined how the Escherichia coli transcriptome changes after loss of PaeR7I gene complex. At earlier time points, activation of SOS genes and sigma(E)-regulon was noticeable. With time, more SOS genes, stress-response genes (including sigma(S)-regulon, osmotic-, oxidative- and periplasmic-stress genes), biofilm-related genes, and many hitherto uncharacterized genes were induced, and genes for energy metabolism, motility and outer membrane biogenesis were repressed. As expected from the activation of sigma(E)-regulon, the death was accompanied by cell lysis and release of cellular proteins. Expression of several sigma(E)-regulon genes indeed led to cell lysis. We hypothesize that some signal was transduced, among multiple genes involved, from the damaged genome to the cell surface and led to its disintegration. These results are discussed in comparison with other forms of programmed deaths in bacteria and eukaryotes. | lld:pubmed |
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| pubmed-article:19304752 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19304752 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19304752 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19304752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19304752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19304752 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19304752 | pubmed:month | May | lld:pubmed |
| pubmed-article:19304752 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:19304752 | pubmed:author | pubmed-author:KobayashiIchi... | lld:pubmed |
| pubmed-article:19304752 | pubmed:author | pubmed-author:AsakuraYokoY | lld:pubmed |
| pubmed-article:19304752 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19304752 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:19304752 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19304752 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19304752 | pubmed:pagination | 3021-31 | lld:pubmed |
| pubmed-article:19304752 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:19304752 | pubmed:meshHeading | pubmed-meshheading:19304752... | lld:pubmed |
| pubmed-article:19304752 | pubmed:year | 2009 | lld:pubmed |
