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pubmed-article:19303876pubmed:abstractTextThe Hypocrea jecorina LXR1 was described as the first fungal L-xylulose reductase responsible for NADPH dependent reduction of L-xylulose to xylitol in L-arabinose catabolism. Phylogenetic analysis now reveals that LXR1 forms a clade with fungal D-mannitol 2-dehydrogenases. Lxr1 and the orthologous Aspergillus niger mtdA are not induced by L-arabinose but expressed at low levels during growth on different carbon sources. Deletion of lxr1 does not affect growth on L-arabinose and L-xylulose reductase activity remains unaltered whereas D-mannitol 2-dehydrogenase activities are reduced. We conclude that LXR1 is a D-mannitol 2-dehydrogenase and that a true LXR1 is still awaiting discovery.lld:pubmed
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pubmed-article:19303876pubmed:authorpubmed-author:PolakStefanSlld:pubmed
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pubmed-article:19303876pubmed:pagination1309-13lld:pubmed
pubmed-article:19303876pubmed:dateRevised2011-4-6lld:pubmed
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pubmed-article:19303876pubmed:year2009lld:pubmed
pubmed-article:19303876pubmed:articleTitleThe Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism.lld:pubmed
pubmed-article:19303876pubmed:affiliationResearch Area Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, TU Vienna, Getreidemarkt 9, A-1060 Wien, Austria.lld:pubmed
pubmed-article:19303876pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19303876pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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