| pubmed-article:19301403 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19301403 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:19301403 | lifeskim:mentions | umls-concept:C0016976 | lld:lifeskim |
| pubmed-article:19301403 | lifeskim:mentions | umls-concept:C0010672 | lld:lifeskim |
| pubmed-article:19301403 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:19301403 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19301403 | pubmed:dateCreated | 2009-4-1 | lld:pubmed |
| pubmed-article:19301403 | pubmed:abstractText | Leucine-rich repeat (LRR) -containing G protein coupled receptor (LGR) family members are characterized by the presence of a seven-transmembrane domain and LRR motifs. We describe a new function for Lgr4 in the development of the gall bladder and cystic duct and in the epithelium-mesenchyme interaction. Lgr4 expression was observed in the gall bladder epithelium when the gall bladder primordium elongated ventrally. Although Lgr4 hypomorphic mutant (Lgr4(Gt/Gt)) embryos developed a normal gall bladder bud at embryonic day (E) 10.25, no further elongation was observed at later stages. At E12.5, the mesenchyme surrounding the gall bladder had completely disappeared in Lgr4(Gt/Gt) embryos, while the gall bladder remained unelongated. Neighboring tissues such as liver and pancreas were unaffected, as revealed by expression of marker genes. This is the first report of a mutant mouse that lacks a gall bladder and cystic duct without affecting the other tissues that derive from the same hepatic diverticulum. | lld:pubmed |
| pubmed-article:19301403 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19301403 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19301403 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19301403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19301403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19301403 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19301403 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19301403 | pubmed:issn | 1058-8388 | lld:pubmed |
| pubmed-article:19301403 | pubmed:author | pubmed-author:YamamuraKen-i... | lld:pubmed |
| pubmed-article:19301403 | pubmed:author | pubmed-author:ArakiKimiK | lld:pubmed |
| pubmed-article:19301403 | pubmed:author | pubmed-author:YamashitaRyoR | lld:pubmed |
| pubmed-article:19301403 | pubmed:author | pubmed-author:HoshiiTakayuk... | lld:pubmed |
| pubmed-article:19301403 | pubmed:author | pubmed-author:YokouchiYujiY | lld:pubmed |
| pubmed-article:19301403 | pubmed:author | pubmed-author:TakegawaYumik... | lld:pubmed |
| pubmed-article:19301403 | pubmed:author | pubmed-author:SakumotoMachi... | lld:pubmed |
| pubmed-article:19301403 | pubmed:author | pubmed-author:NakaharaMaiM | lld:pubmed |
| pubmed-article:19301403 | pubmed:author | pubmed-author:KawazuHarunaH | lld:pubmed |
| pubmed-article:19301403 | pubmed:copyrightInfo | Copyright 2009 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:19301403 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19301403 | pubmed:volume | 238 | lld:pubmed |
| pubmed-article:19301403 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19301403 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19301403 | pubmed:pagination | 993-1000 | lld:pubmed |
| pubmed-article:19301403 | pubmed:meshHeading | pubmed-meshheading:19301403... | lld:pubmed |
| pubmed-article:19301403 | pubmed:meshHeading | pubmed-meshheading:19301403... | lld:pubmed |
| pubmed-article:19301403 | pubmed:meshHeading | pubmed-meshheading:19301403... | lld:pubmed |
| pubmed-article:19301403 | pubmed:meshHeading | pubmed-meshheading:19301403... | lld:pubmed |
| pubmed-article:19301403 | pubmed:meshHeading | pubmed-meshheading:19301403... | lld:pubmed |
| pubmed-article:19301403 | pubmed:meshHeading | pubmed-meshheading:19301403... | lld:pubmed |
| pubmed-article:19301403 | pubmed:meshHeading | pubmed-meshheading:19301403... | lld:pubmed |
| pubmed-article:19301403 | pubmed:meshHeading | pubmed-meshheading:19301403... | lld:pubmed |
| pubmed-article:19301403 | pubmed:meshHeading | pubmed-meshheading:19301403... | lld:pubmed |
| pubmed-article:19301403 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19301403 | pubmed:articleTitle | Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice. | lld:pubmed |
| pubmed-article:19301403 | pubmed:affiliation | Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan. | lld:pubmed |
| pubmed-article:19301403 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19301403 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:11576 | entrezgene:pubmed | pubmed-article:19301403 | lld:entrezgene |
| entrez-gene:11657 | entrezgene:pubmed | pubmed-article:19301403 | lld:entrezgene |
| entrez-gene:18609 | entrezgene:pubmed | pubmed-article:19301403 | lld:entrezgene |
| entrez-gene:107515 | entrezgene:pubmed | pubmed-article:19301403 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19301403 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19301403 | lld:pubmed |
