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pubmed-article:19281805pubmed:abstractTextChronic hepatitis induced liver fibrogenesis is characterized by epithelial-to-mesenchymal transition of liver parenchymal cells (hepatocytes) to fibroblast (-like cells), i.e. increasing hepatocellular dedifferentiation, ultimatively leading to the development of hepatocellular carcinoma (HCC). Up to now the spectrum of valid serum biomarkers for this process of hepatocellular dedifferentiation is very limited. We therefore investigated the dynamics of alterations in the serum transferrin isoform pattern in the pathogenetic sequence from liver fibrosis to hepatocellular carcinoma, to evaluate the suitability of one of the isoforms as potential biomarker for hepatocellular dedifferentiation in chronic liver disease.lld:pubmed
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pubmed-article:19281805pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:19281805pubmed:articleTitleEvaluation of serum percent trisialotransferrin as potential predictive biomarker of hepatocellular dedifferentiation in chronic liver disease.lld:pubmed
pubmed-article:19281805pubmed:affiliationInstitute of Clinical Chemistry and Pathobiochemistry/Central Laboratory, RWTH-University Hospital, Aachen, Germany. ogressner@ukaachen.delld:pubmed
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