| pubmed-article:19246717 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19246717 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:19246717 | lifeskim:mentions | umls-concept:C0020542 | lld:lifeskim |
| pubmed-article:19246717 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:19246717 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:19246717 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:19246717 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:19246717 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19246717 | pubmed:dateCreated | 2009-5-21 | lld:pubmed |
| pubmed-article:19246717 | pubmed:abstractText | It has been proposed that an activated renin angiotensin system (RAS) causes an imbalance between the vasoconstrictive and vasodilator mechanisms involving the pulmonary circulation leading to the development of pulmonary hypertension (PH). Recent studies have indicated that angiotensin-converting enzyme 2 (ACE2), a member of the vasoprotective axis of the RAS, plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Based on these observations, we propose the hypothesis that activation of endogenous ACE2 can shift the balance from the vasoconstrictive, proliferative axis (ACE-Ang II-AT1R) to the vasoprotective axis [ACE2-Ang-(1-7)-Mas] of the RAS, resulting in the prevention of PH. | lld:pubmed |
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| pubmed-article:19246717 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19246717 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:19246717 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19246717 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19246717 | pubmed:issn | 1535-4970 | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:OstrovDavid... | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:KatovichMicha... | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:CastellanoRon... | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:FerreiraAnder... | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:RaizadaMohan... | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:OhSuk PaulSP | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:FrancisJoseph... | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:YamazatoYorik... | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:SrinivasSrira... | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:YuanLihuiL | lld:pubmed |
| pubmed-article:19246717 | pubmed:author | pubmed-author:ShenoyVinayak... | lld:pubmed |
| pubmed-article:19246717 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19246717 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19246717 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:19246717 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19246717 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19246717 | pubmed:pagination | 1048-54 | lld:pubmed |
| pubmed-article:19246717 | pubmed:dateRevised | 2010-9-23 | lld:pubmed |
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| pubmed-article:19246717 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19246717 | pubmed:articleTitle | Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension. | lld:pubmed |
| pubmed-article:19246717 | pubmed:affiliation | Department of Physiology and Functional Genomics, College of Medicine, Gainesville, FL 32610, USA. | lld:pubmed |
| pubmed-article:19246717 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19246717 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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