| pubmed-article:1922076 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1922076 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:1922076 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:1922076 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:1922076 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:1922076 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:1922076 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1922076 | lifeskim:mentions | umls-concept:C1548602 | lld:lifeskim |
| pubmed-article:1922076 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:1922076 | lifeskim:mentions | umls-concept:C0971887 | lld:lifeskim |
| pubmed-article:1922076 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1922076 | pubmed:dateCreated | 1991-11-14 | lld:pubmed |
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| pubmed-article:1922076 | pubmed:abstractText | The mb-1 gene, encoding a membrane immunoglobulin-associated protein, is developmentally regulated and expressed specifically in pre-B and mature B lymphocytes. Analysis of the TATA-less mb-1 promoter indicated that it directs initiation of transcription from multiple sites. Promoter sequences between -68 and +70 conferred the correct pattern of cell type-specific transcription upon a heterologous gene. Two nuclear factor-binding sites that are important for promoter function were identified between -59 and -38. Both sites interacted with ubiquitous nuclear factors in vitro. One of these factors was identified as Sp1. Multimerized copies of both factor-binding sites augmented expression from a heterologous minimal promoter in both lymphoid and nonlymphoid cells, suggesting that additional mb-1 promoter sequences are involved in determining the correct cell type specificity. Analysis of the heterogeneity of transcription initiation indicated that a mutation which increased the distance between upstream sequences and the region of initiation resulted in the utilization of a novel set of initiation sites. Moreover, an insertion of a TATA element into the mb-1 promoter at -30 biased initiation of transcription to +1 but did not abolish the use of the other sites. Mutation of an initiator sequence homology encompassing one of the major initiation sites had only a minor effect on its utilization. From these data, we conclude that upstream factor-binding sites in the TATA-less mb-1 promoter define a region in which initiation of transcription occurs at multiple sites. | lld:pubmed |
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| pubmed-article:1922076 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1922076 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922076 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1922076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1922076 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1922076 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1922076 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1922076 | pubmed:author | pubmed-author:GrosschedlRR | lld:pubmed |
| pubmed-article:1922076 | pubmed:author | pubmed-author:TravisAA | lld:pubmed |
| pubmed-article:1922076 | pubmed:author | pubmed-author:HagmanJJ | lld:pubmed |
| pubmed-article:1922076 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1922076 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1922076 | pubmed:geneSymbol | mb-1 | lld:pubmed |
| pubmed-article:1922076 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1922076 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1922076 | pubmed:pagination | 5756-66 | lld:pubmed |
| pubmed-article:1922076 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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