| pubmed-article:1922040 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1922040 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:1922040 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:1922040 | lifeskim:mentions | umls-concept:C0021034 | lld:lifeskim |
| pubmed-article:1922040 | lifeskim:mentions | umls-concept:C0598666 | lld:lifeskim |
| pubmed-article:1922040 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1922040 | pubmed:dateCreated | 1991-10-31 | lld:pubmed |
| pubmed-article:1922040 | pubmed:abstractText | In the accompanying report (C. F. Webb, C. Das, S. Eaton, K. Calame, and P. Tucker, Mol. Cell. Biol. 11:5197-5205, 1991), we characterize B-cell-specific protein-DNA interactions at -500 and -200 bp upstream of the mu immunoglobulin heavy chain promoter whose abundances were increased by interleukin-5 plus antigen. Because of the high A + T/G + C ratio of these sequences and the consistent findings by others that enhancer- and promoterlike regions are often located near matrix-associated regions, we asked whether these sequences might also be involved in binding to the nuclear matrix. Indeed, DNA fragments containing the -500 binding site were bound by nuclear matrix proteins. Furthermore, UV cross-linking studies showed that the DNA binding site for interleukin-5-plus-antigen-inducible proteins could also bind to proteins solubilized from the nuclear matrix. Nuclear matrix-associated sequences have also been demonstrated on either side of the intronic immunoglobulin heavy chain enhancer. Our data suggest a topological model by which interactions among proteins bound to the promoter and distal enhancer sequences might occur. | lld:pubmed |
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| pubmed-article:1922040 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1922040 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1922040 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1922040 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1922040 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1922040 | pubmed:author | pubmed-author:TuckerP WPW | lld:pubmed |
| pubmed-article:1922040 | pubmed:author | pubmed-author:DaiYY | lld:pubmed |
| pubmed-article:1922040 | pubmed:author | pubmed-author:WebbC FCF | lld:pubmed |
| pubmed-article:1922040 | pubmed:author | pubmed-author:EneffK LKL | lld:pubmed |
| pubmed-article:1922040 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1922040 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1922040 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1922040 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1922040 | pubmed:pagination | 5206-11 | lld:pubmed |
| pubmed-article:1922040 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1922040 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1922040 | pubmed:articleTitle | Identification of a matrix-associated region 5' of an immunoglobulin heavy chain variable region gene. | lld:pubmed |
| pubmed-article:1922040 | pubmed:affiliation | Department of Immunobiology, Oklahoma Medical Research Foundation, Oklahoma City 73104. | lld:pubmed |
| pubmed-article:1922040 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1922040 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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