| pubmed-article:19219023 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19219023 | lifeskim:mentions | umls-concept:C1906603 | lld:lifeskim |
| pubmed-article:19219023 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19219023 | lifeskim:mentions | umls-concept:C0024075 | lld:lifeskim |
| pubmed-article:19219023 | lifeskim:mentions | umls-concept:C1708481 | lld:lifeskim |
| pubmed-article:19219023 | lifeskim:mentions | umls-concept:C1071328 | lld:lifeskim |
| pubmed-article:19219023 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:19219023 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19219023 | pubmed:dateCreated | 2009-3-6 | lld:pubmed |
| pubmed-article:19219023 | pubmed:abstractText | We developed a new approach to bioluminescent T cell imaging using a membrane-anchored form of the Gaussia luciferase (GLuc) enzyme, termed extGLuc, which we could stably express in both mouse and human primary T cells. In vitro, extGLuc+ cells emitted significantly higher bioluminescent signal when compared to cells expressing GLuc, Renilla luciferase (RLuc) or membrane-anchored RLuc (extRLuc). In vivo, mouse extGLuc+ T cells showed higher bioluminescent signal when compared to GLuc+ and RLuc+ T cells. Application of this imaging approach to human T cells genetically modified to express tumor-specific chimeric antigen receptors (CARs) enabled us to show in vivo CAR-mediated T cell accumulation in tumor, T cell persistence over time and concomitant imaging of T cells and tumor cells modified to express firefly luciferase. This sensitive imaging technology has application to many in vivo cell-based studies in a wide array of mouse models. | lld:pubmed |
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| pubmed-article:19219023 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19219023 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19219023 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19219023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19219023 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19219023 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19219023 | pubmed:issn | 1546-170X | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:BrentjensReni... | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:SadelainMiche... | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:LarsonSteven... | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:LeeJamesJ | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:YehRaymondR | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:SantosElmer... | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:La... | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:NikhaminYanY | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:PunzalanBlesi... | lld:pubmed |
| pubmed-article:19219023 | pubmed:author | pubmed-author:PunzalanBless... | lld:pubmed |
| pubmed-article:19219023 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19219023 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:19219023 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19219023 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19219023 | pubmed:pagination | 338-44 | lld:pubmed |
| pubmed-article:19219023 | pubmed:dateRevised | 2011-5-16 | lld:pubmed |
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| pubmed-article:19219023 | pubmed:meshHeading | pubmed-meshheading:19219023... | lld:pubmed |
| pubmed-article:19219023 | pubmed:meshHeading | pubmed-meshheading:19219023... | lld:pubmed |
| pubmed-article:19219023 | pubmed:meshHeading | pubmed-meshheading:19219023... | lld:pubmed |
| pubmed-article:19219023 | pubmed:meshHeading | pubmed-meshheading:19219023... | lld:pubmed |
| pubmed-article:19219023 | pubmed:meshHeading | pubmed-meshheading:19219023... | lld:pubmed |
| pubmed-article:19219023 | pubmed:meshHeading | pubmed-meshheading:19219023... | lld:pubmed |
| pubmed-article:19219023 | pubmed:meshHeading | pubmed-meshheading:19219023... | lld:pubmed |
| pubmed-article:19219023 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19219023 | pubmed:articleTitle | Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase. | lld:pubmed |
| pubmed-article:19219023 | pubmed:affiliation | Department of Radiology, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, New York 10021, USA. | lld:pubmed |
| pubmed-article:19219023 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19219023 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19219023 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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