| pubmed-article:1920600 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1920600 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:1920600 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:1920600 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:1920600 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:1920600 | lifeskim:mentions | umls-concept:C0039925 | lld:lifeskim |
| pubmed-article:1920600 | lifeskim:mentions | umls-concept:C1579762 | lld:lifeskim |
| pubmed-article:1920600 | lifeskim:mentions | umls-concept:C0009491 | lld:lifeskim |
| pubmed-article:1920600 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1920600 | pubmed:dateCreated | 1991-11-8 | lld:pubmed |
| pubmed-article:1920600 | pubmed:abstractText | The central arterial pharmacokinetics of thiopental were studied in six rabbits, six sheep and six dogs after a short infusion at approximately 10 mg/kg min. Thiopental was infused to a defined electro-encephalographic endpoint (EEG burst suppression). The time to reach early burst suppression was longer in the dog (3.9 +/- 0.5 min) compared with the sheep (3.0 +/- 0.6 min) and the rabbit (2.5 +/- 0.5 min). The total dose required to produce the same level of EEG activity was higher in the dog (35.9 +/- 6.8 mg/kg) compared with the sheep (24.3 +/- 5.3 mg/kg) and the rabbit (21.6 +/- 6.8 mg/kg). The plasma concentration-time data for each animal was fitted using non-linear regression to a bi- or tri-exponential function. In all animals, the plasma-time profile was best described as a tri-exponential decay. The initial volume of distribution was similar in all three species (rabbit, 38.6 +/- 10.0 mg/kg; sheep, 44.5 +/- 9.1 ml/kg; dog, 38.1 +/- 18.4 ml/kg). The maximum arterial plasma thiopental concentration achieved at EEG burst suppression was higher in the sheep (221.8 +/- 27.9 micrograms/ml) than the dog (164.7 +/- 29.9 micrograms/ml) or the rabbit (112.3 +/- 15.1 micrograms/ml). Thiopental distribution clearance was slower in the sheep (43.6 +/- 15.1 ml/min/kg) compared with the rabbit (110.5 +/- 18.7 ml/min kg) and the dog (97.2 +/- 47.2 ml/min kg). Elimination half-life was extended in the sheep (251.9 +/- 107.8 min) and dog (182.4 +/- 57.9 min) relative to the rabbit (43.1 +/- 3.4 min).(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1920600 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1920600 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1920600 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1920600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1920600 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1920600 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1920600 | pubmed:issn | 0140-7783 | lld:pubmed |
| pubmed-article:1920600 | pubmed:author | pubmed-author:IlkiwJ EJE | lld:pubmed |
| pubmed-article:1920600 | pubmed:author | pubmed-author:McNealDD | lld:pubmed |
| pubmed-article:1920600 | pubmed:author | pubmed-author:EblingW FWF | lld:pubmed |
| pubmed-article:1920600 | pubmed:author | pubmed-author:BenthuysenJ... | lld:pubmed |
| pubmed-article:1920600 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1920600 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:1920600 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1920600 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1920600 | pubmed:pagination | 134-40 | lld:pubmed |
| pubmed-article:1920600 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:meshHeading | pubmed-meshheading:1920600-... | lld:pubmed |
| pubmed-article:1920600 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1920600 | pubmed:articleTitle | A comparative study of the pharmacokinetics of thiopental in the rabbit, sheep and dog. | lld:pubmed |
| pubmed-article:1920600 | pubmed:affiliation | Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616. | lld:pubmed |
| pubmed-article:1920600 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1920600 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1920600 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
