| pubmed-article:19202052 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19202052 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19202052 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:19202052 | lifeskim:mentions | umls-concept:C0032863 | lld:lifeskim |
| pubmed-article:19202052 | lifeskim:mentions | umls-concept:C0205125 | lld:lifeskim |
| pubmed-article:19202052 | lifeskim:mentions | umls-concept:C0599883 | lld:lifeskim |
| pubmed-article:19202052 | lifeskim:mentions | umls-concept:C1511693 | lld:lifeskim |
| pubmed-article:19202052 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:19202052 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19202052 | pubmed:dateCreated | 2009-3-11 | lld:pubmed |
| pubmed-article:19202052 | pubmed:abstractText | The ability to sequence cost-effectively all of the coding regions of a given individual genome is rapidly approaching, with the potential for whole-genome resequencing not far behind. Initiatives are currently underway to phenotype hundreds of thousands of individuals for major human traits. Here, we determine the power for de novo discovery of genes related to human traits by resequencing all human exons in a clinical population. We analyze the potential of the gene discovery strategy that combines multiple rare variants from the same gene and treats genes, rather than individual alleles, as the units for the association test. By using computer simulations based on deep resequencing data for the European population, we show that genes meaningfully affecting a human trait can be identified in an unbiased fashion, although large sample sizes would be required to achieve substantial power. | lld:pubmed |
| pubmed-article:19202052 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19202052 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19202052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19202052 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19202052 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19202052 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19202052 | pubmed:author | pubmed-author:KryukovGregor... | lld:pubmed |
| pubmed-article:19202052 | pubmed:author | pubmed-author:SunyaevShamil... | lld:pubmed |
| pubmed-article:19202052 | pubmed:author | pubmed-author:Stamatoyannop... | lld:pubmed |
| pubmed-article:19202052 | pubmed:author | pubmed-author:ShpuntAlexand... | lld:pubmed |
| pubmed-article:19202052 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19202052 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:19202052 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19202052 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19202052 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19202052 | pubmed:pagination | 3871-6 | lld:pubmed |
| pubmed-article:19202052 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:meshHeading | pubmed-meshheading:19202052... | lld:pubmed |
| pubmed-article:19202052 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19202052 | pubmed:articleTitle | Power of deep, all-exon resequencing for discovery of human trait genes. | lld:pubmed |
| pubmed-article:19202052 | pubmed:affiliation | Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:19202052 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19202052 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19202052 | lld:pubmed |
