Linked Life Data

19202004

Source:http://linkedlifedata.com/resource/pubmed/id/19202004

Statements in which the resource exists.
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pubmed-article:19202004pubmed:abstractTextEffective protective immunity against respiratory infections with intracellular pathogens requires pathogen-specific cytotoxic T cells (CTL) in the lung. However, vaccines that induce pathogen-specific CTL in the lung are poorly explored. Dendritic cells (DC) have increasingly been exploited as vaccines against infections. However, few studies have investigated the ability of mucosal DC vaccines to elicit protective CTL responses in the lung. Our objective was to develop an efficacious mucosal DC vaccine to generate protective CTL against respiratory infections with intracellular pathogens. Bone marrow-derived DC (BM-DC) pulsed with a single immunodominant CTL epitope, listeriolysin O (LLO) 91-99, of Listeria monocytogenes (LM) were intratracheally administered into mice. The frequency and function of epitope-specific CTL in mediastinal lymph nodes (MLN) and spleen were assessed for their ability to protect against LM infection. After intratracheal administration, lipopolysaccharide (LPS)-treated LLO 91-99-loaded BM-DC (LPS-LLO DC) more frequently migrated to MLN than LPS-untreated LLO 91-99-loaded BM-DC (LLO DC). Using tetrameric H2-K(d)/LLO 91-99 peptide complex, specific CD8(+) T cells were found in MLN as well as the spleen in LPS-LLO DC-immunized mice, but not in LLO-DC-immunized mice. Both MLN and spleen cells obtained from LPS-LLO DC-immunized mice produced large amounts of IFN-gamma in response to LLO 91-99 with high epitope-specific CTL activities. Vaccination with LPS-LLO DC, but not LLO DC, protected mice against lethal respiratory infection with LM. These data suggest that mucosal vaccination with LPS-treated immunodominant CTL epitope-loaded DC is a promising strategy for generating protective CTL against respiratory infections with intracellular pathogens.lld:pubmed
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pubmed-article:19202004pubmed:monthOctlld:pubmed
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pubmed-article:19202004pubmed:authorpubmed-author:NakamuraHirot...lld:pubmed
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pubmed-article:19202004pubmed:pagination440-8lld:pubmed
pubmed-article:19202004pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:19202004pubmed:year2009lld:pubmed
pubmed-article:19202004pubmed:articleTitleMucosal vaccine using CTL epitope-pulsed dendritic cell confers protection for intracellular pathogen.lld:pubmed
pubmed-article:19202004pubmed:affiliationDepartment of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.lld:pubmed
pubmed-article:19202004pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19202004pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed