Linked Life Data

19193788

Source:http://linkedlifedata.com/resource/pubmed/id/19193788

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:19193788rdf:typepubmed:Citationlld:pubmed
pubmed-article:19193788lifeskim:mentionsumls-concept:C0019704lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C1332717lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C1706438lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C0039194lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C0085358lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C1327616lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C2350332lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C0040649lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C1413244lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C2698600lld:lifeskim
pubmed-article:19193788lifeskim:mentionsumls-concept:C0301625lld:lifeskim
pubmed-article:19193788pubmed:issue9lld:pubmed
pubmed-article:19193788pubmed:dateCreated2009-4-10lld:pubmed
pubmed-article:19193788pubmed:abstractTextCD8(+) T cells display a noncytotoxic activity that suppresses transcription of human immunodeficiency virus type 1 (HIV-1) in an antigen-independent and major histocompatibility complex-unrestricted manner. To date, the precise cellular and molecular factors mediating this CD8(+) T-cell effector function remain unsolved. Despite evidence indicating the dependence of the activity on cell-cell contact, the possibility of a membrane-mediated activity that represses transcription from the viral promoter remains unexplored. We therefore investigated whether this inhibition of HIV-1 transcription might be elicited by a membrane-bound determinant. Using a CD8(+) T-cell line displaying potent noncytotoxic HIV-1 suppression activity, we have identified a membrane-localized HIV-1-suppressing activity that is concomitantly secreted as 30- to 100-nm endosome-derived tetraspanin-rich vesicles known as exosomes. Purified exosomes from CD8(+) T-cell culture supernatant noncytotoxically suppressed CCR5-tropic (R5) and CXCR4-tropic (X4) replication of HIV-1 in vitro through a protein moiety. Similar antiviral activity was also found in exosomes isolated from two HIV-1-infected subjects. The antiviral exosomes specifically inhibited HIV-1 transcription in both acute and chronic models of infection. Our results, for the first time, indicate the existence of an antiviral membrane-bound factor consistent with the hallmarks defining noncytotoxic CD8(+) T-cell suppression of HIV-1.lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:languageenglld:pubmed
pubmed-article:19193788pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:citationSubsetIMlld:pubmed
pubmed-article:19193788pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19193788pubmed:statusMEDLINElld:pubmed
pubmed-article:19193788pubmed:monthMaylld:pubmed
pubmed-article:19193788pubmed:issn1098-5514lld:pubmed
pubmed-article:19193788pubmed:authorpubmed-author:WatkinsSimon...lld:pubmed
pubmed-article:19193788pubmed:authorpubmed-author:ChenYueYlld:pubmed
pubmed-article:19193788pubmed:authorpubmed-author:GuptaPhalguni...lld:pubmed
pubmed-article:19193788pubmed:authorpubmed-author:StolzDonna...lld:pubmed
pubmed-article:19193788pubmed:authorpubmed-author:DingMingMlld:pubmed
pubmed-article:19193788pubmed:authorpubmed-author:SahaKunalKlld:pubmed
pubmed-article:19193788pubmed:authorpubmed-author:TumneAshwinAlld:pubmed
pubmed-article:19193788pubmed:authorpubmed-author:PrasadVarsha...lld:pubmed
pubmed-article:19193788pubmed:authorpubmed-author:RatnerDeena...lld:pubmed
pubmed-article:19193788pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19193788pubmed:volume83lld:pubmed
pubmed-article:19193788pubmed:ownerNLMlld:pubmed
pubmed-article:19193788pubmed:authorsCompleteYlld:pubmed
pubmed-article:19193788pubmed:pagination4354-64lld:pubmed
pubmed-article:19193788pubmed:dateRevised2010-9-23lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
pubmed-article:19193788pubmed:meshHeadingpubmed-meshheading:19193788...lld:pubmed
More...