pubmed-article:19180500 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:19180500 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
pubmed-article:19180500 | lifeskim:mentions | umls-concept:C1861303 | lld:lifeskim |
pubmed-article:19180500 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
pubmed-article:19180500 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
pubmed-article:19180500 | lifeskim:mentions | umls-concept:C1457869 | lld:lifeskim |
pubmed-article:19180500 | lifeskim:mentions | umls-concept:C1826449 | lld:lifeskim |
pubmed-article:19180500 | lifeskim:mentions | umls-concept:C1979886 | lld:lifeskim |
pubmed-article:19180500 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:19180500 | pubmed:dateCreated | 2009-2-9 | lld:pubmed |
pubmed-article:19180500 | pubmed:abstractText | Blau syndrome is a rare, autosomal-dominant, autoinflammatory disorder characterized by granulomatous arthritis, uveitis, and dermatitis. Genetics studies have shown that the disease is caused by single nonsynonymous substitutions in NOD-2, a member of the NOD-like receptor or NACHT-leucine-rich repeat (NLR) family of intracellular proteins. Several NLRs function in the innate immune system as sensors of pathogen components and participate in immune-mediated cellular responses via the caspase 1 inflammasome. Mutations in a gene related to NOD-2, NLRP3, are responsible for excess caspase 1-dependent interleukin-1beta (IL-1beta) in cryopyrinopathies such as Muckle-Wells syndrome. Furthermore, functional studies demonstrate that caspase 1-mediated release of IL-1beta also involves NOD-2. The aim of this study was to test the hypothesis that IL-1beta may mediate the inflammation seen in patients with Blau syndrome. | lld:pubmed |
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pubmed-article:19180500 | pubmed:language | eng | lld:pubmed |
pubmed-article:19180500 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19180500 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:19180500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:19180500 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:19180500 | pubmed:month | Feb | lld:pubmed |
pubmed-article:19180500 | pubmed:issn | 0004-3591 | lld:pubmed |
pubmed-article:19180500 | pubmed:author | pubmed-author:ChenHongH | lld:pubmed |
pubmed-article:19180500 | pubmed:author | pubmed-author:RosenbaumJame... | lld:pubmed |
pubmed-article:19180500 | pubmed:author | pubmed-author:MartinTammy... | lld:pubmed |
pubmed-article:19180500 | pubmed:author | pubmed-author:DaveyMichael... | lld:pubmed |
pubmed-article:19180500 | pubmed:author | pubmed-author:ZhangZiliZ | lld:pubmed |
pubmed-article:19180500 | pubmed:author | pubmed-author:LuHuiyingH | lld:pubmed |
pubmed-article:19180500 | pubmed:author | pubmed-author:RoséCarlos... | lld:pubmed |
pubmed-article:19180500 | pubmed:author | pubmed-author:PlanckStephen... | lld:pubmed |
pubmed-article:19180500 | pubmed:author | pubmed-author:KurzPaulP | lld:pubmed |
pubmed-article:19180500 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:19180500 | pubmed:volume | 60 | lld:pubmed |
pubmed-article:19180500 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:19180500 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:19180500 | pubmed:pagination | 611-8 | lld:pubmed |
pubmed-article:19180500 | pubmed:dateRevised | 2011-3-11 | lld:pubmed |
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