| pubmed-article:19162556 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19162556 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:19162556 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:19162556 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19162556 | pubmed:dateCreated | 2009-4-6 | lld:pubmed |
| pubmed-article:19162556 | pubmed:abstractText | Recently it has become clear that a reduction of IgD-CD27+ memory B-cells in adult CVID patients correlates with clinical aspects of the disease. However, little is known about B-cell dysregulation in pediatric antibody deficiency. Reference values are essential for the interpretation of B-cell subpopulations in children. We present the clinical and immunophenotypical characterization of 16 children and adolescents with CVID and hypogammaglobulinemia. Reference values for IgD+CD27-, IgD+CD27+ and IgD-CD27+ B-cells in healthy children were established for five age groups. In healthy controls we found a continuous increase in IgD-CD27+ B-cell percentage with age from 1.35-5% of B-cells in the second year of life to 4.1-18.7% in adolescents. Interestingly, in 12/14 antibody-deficient patients memory B-cells are significantly below the age-related 10th percentile. We conclude that the reduction of memory B-cells is a useful additional marker for the detection of children with CVID hypogammaglobulinemia and may contribute to the early presentation. | lld:pubmed |
| pubmed-article:19162556 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19162556 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19162556 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19162556 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19162556 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19162556 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19162556 | pubmed:issn | 1521-7035 | lld:pubmed |
| pubmed-article:19162556 | pubmed:author | pubmed-author:NiehuesTimT | lld:pubmed |
| pubmed-article:19162556 | pubmed:author | pubmed-author:FeyenOliverO | lld:pubmed |
| pubmed-article:19162556 | pubmed:author | pubmed-author:HuckKirstenK | lld:pubmed |
| pubmed-article:19162556 | pubmed:author | pubmed-author:GhoshSujalS | lld:pubmed |
| pubmed-article:19162556 | pubmed:author | pubmed-author:BeltzKathrinK | lld:pubmed |
| pubmed-article:19162556 | pubmed:author | pubmed-author:BellertSvenS | lld:pubmed |
| pubmed-article:19162556 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19162556 | pubmed:volume | 131 | lld:pubmed |
| pubmed-article:19162556 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19162556 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19162556 | pubmed:pagination | 50-9 | lld:pubmed |
| pubmed-article:19162556 | pubmed:dateRevised | 2009-12-8 | lld:pubmed |
| pubmed-article:19162556 | pubmed:meshHeading | pubmed-meshheading:19162556... | lld:pubmed |
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| pubmed-article:19162556 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19162556 | pubmed:articleTitle | Memory B-cells in healthy and antibody-deficient children. | lld:pubmed |
| pubmed-article:19162556 | pubmed:affiliation | Department of Pediatric Oncology, Hematology and Clinical Immunology, Centre for Child and Adolescent Health, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany. | lld:pubmed |
| pubmed-article:19162556 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19162556 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
