| pubmed-article:19161276 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19161276 | lifeskim:mentions | umls-concept:C0028606 | lld:lifeskim |
| pubmed-article:19161276 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19161276 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19161276 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19161276 | pubmed:dateCreated | 2009-2-16 | lld:pubmed |
| pubmed-article:19161276 | pubmed:abstractText | A general method for preparing optically pure guanidine-based gamma-peptide nucleic acid (gammaGPNA) monomers for all four natural nucleobases (A, C, G, and T) is described. These second-generation gammaGPNAs differ from the first-generation GPNAs in that the guanidinium group is installed at the gamma- instead of the alpha-position of the N-(2-aminoethyl)glycine backbone unit. This positional switch enables GPNAs to be synthesized from relatively cheap L- as opposed to D-amino acids. Unlike their alpha-predecessors, which are randomly folded, gammaGPNAs prepared from L-amino acids are preorganized into a right-handed helix and bind to DNA and RNA with exceptionally high affinity and sequence selectivity and are readily taken up by mammalian cells. | lld:pubmed |
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| pubmed-article:19161276 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19161276 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19161276 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19161276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19161276 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19161276 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19161276 | pubmed:issn | 1520-6904 | lld:pubmed |
| pubmed-article:19161276 | pubmed:author | pubmed-author:LivakKenneth... | lld:pubmed |
| pubmed-article:19161276 | pubmed:author | pubmed-author:LyDanith HDH | lld:pubmed |
| pubmed-article:19161276 | pubmed:author | pubmed-author:ThomasSufi... | lld:pubmed |
| pubmed-article:19161276 | pubmed:author | pubmed-author:ZonGeraldG | lld:pubmed |
| pubmed-article:19161276 | pubmed:author | pubmed-author:LathropKira... | lld:pubmed |
| pubmed-article:19161276 | pubmed:author | pubmed-author:ChennaVenugop... | lld:pubmed |
| pubmed-article:19161276 | pubmed:author | pubmed-author:SahuBichismit... | lld:pubmed |
| pubmed-article:19161276 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19161276 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:19161276 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:19161276 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19161276 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19161276 | pubmed:pagination | 1509-16 | lld:pubmed |
| pubmed-article:19161276 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19161276 | pubmed:meshHeading | pubmed-meshheading:19161276... | lld:pubmed |
| pubmed-article:19161276 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19161276 | pubmed:articleTitle | Synthesis of conformationally preorganized and cell-permeable guanidine-based gamma-peptide nucleic acids (gammaGPNAs). | lld:pubmed |
| pubmed-article:19161276 | pubmed:affiliation | Department of Chemistry and Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA. | lld:pubmed |
| pubmed-article:19161276 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19161276 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19161276 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
