| pubmed-article:19133500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19133500 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:19133500 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19133500 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:19133500 | lifeskim:mentions | umls-concept:C0870071 | lld:lifeskim |
| pubmed-article:19133500 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:19133500 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19133500 | pubmed:dateCreated | 2009-1-12 | lld:pubmed |
| pubmed-article:19133500 | pubmed:abstractText | Bacteria in a biofilm are enmeshed in a self-synthesized extracellular polysaccharide matrix (PGA), which is a linear polymer of beta(1,6)-linked N-acetylglucosamine (GlcNAc) residues. Dispersin B (DspB), a soluble glycoside hydrolase produced by the periodontal pathogen Actinobacillus actinomycetemcomitans degrades PGA. The enzyme DspB is an alpha/beta TIM-barrel protein and belongs to family 20 glycosyl hydrolases members. The enzyme activity of DspB with regard to its substrate specificity towards beta(1,6)-linked GlcNAc polymers and its endo/exo character was investigated through ligand docking and the hydrolysis of synthetic oligosaccharides. Ligand docking analysis suggested that beta(1,6)-linked GlcNAc oligosaccharide bound to the active site better that beta(1,4)-linked GlcNAc oligosaccharide. Our combined results indicate that DspB is an exo-acting enzyme that hydrolyzes beta(1,6)-linked N-acetylglucosamine oligomers. | lld:pubmed |
| pubmed-article:19133500 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19133500 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19133500 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19133500 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19133500 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19133500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19133500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19133500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19133500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19133500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19133500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19133500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19133500 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19133500 | pubmed:issn | 0236-5383 | lld:pubmed |
| pubmed-article:19133500 | pubmed:author | pubmed-author:LiptákAA | lld:pubmed |
| pubmed-article:19133500 | pubmed:author | pubmed-author:KaplanJ BJB | lld:pubmed |
| pubmed-article:19133500 | pubmed:author | pubmed-author:RamasubbuNN | lld:pubmed |
| pubmed-article:19133500 | pubmed:author | pubmed-author:KerriganJ EJE | lld:pubmed |
| pubmed-article:19133500 | pubmed:author | pubmed-author:RagunathCC | lld:pubmed |
| pubmed-article:19133500 | pubmed:author | pubmed-author:JánossyLL | lld:pubmed |
| pubmed-article:19133500 | pubmed:author | pubmed-author:GyémántGyöngy... | lld:pubmed |
| pubmed-article:19133500 | pubmed:author | pubmed-author:KandraLiliL | lld:pubmed |
| pubmed-article:19133500 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19133500 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:19133500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19133500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19133500 | pubmed:pagination | 439-51 | lld:pubmed |
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| pubmed-article:19133500 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:19133500 | pubmed:articleTitle | Modeling and biochemical analysis of the activity of antibiofilm agent Dispersin B. | lld:pubmed |
| pubmed-article:19133500 | pubmed:affiliation | Academic Systems and Technologies, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. | lld:pubmed |
| pubmed-article:19133500 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19133500 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19133500 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19133500 | lld:pubmed |
