| pubmed-article:19072828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19072828 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:19072828 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:19072828 | lifeskim:mentions | umls-concept:C0205466 | lld:lifeskim |
| pubmed-article:19072828 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:19072828 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:19072828 | lifeskim:mentions | umls-concept:C0205462 | lld:lifeskim |
| pubmed-article:19072828 | lifeskim:mentions | umls-concept:C1522577 | lld:lifeskim |
| pubmed-article:19072828 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:19072828 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:19072828 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19072828 | pubmed:dateCreated | 2009-3-3 | lld:pubmed |
| pubmed-article:19072828 | pubmed:abstractText | One hundred fifty patients with sustained virologic response (SVR) after treatment of chronic hepatitis C were enrolled in a long-term clinical follow-up study; patients were followed for 5 years for liver-related outcomes and evidence of biochemical or virologic relapse. Patients with stage 2 or greater fibrosis on pretreatment biopsy were invited to undergo a long-term follow-up biopsy after their fourth year of follow-up. One hundred twenty-eight patients (85%) were followed through their fourth year, and long-term follow-up biopsies were obtained from 60 patients (40%). Forty-nine patients had paired pretreatment and long-term follow-up biopsies blindly rescored. Forty of these patients (82%) had a decrease in fibrosis score, and 45 (92%) had a decrease in combined inflammation score. Ten patients (20%) had normal or nearly normal livers on long-term follow-up biopsy. Two patients with pretreatment cirrhosis developed hepatocellular carcinoma (HCC), and one died. All the other patients with pretreatment cirrhosis or advanced fibrosis had improved fibrosis scores on long-term follow-up biopsy. No patient had conclusive evidence of virologic relapse. Three patients had persistently elevated alanine aminotransferase levels; two of these had new liver disease. CONCLUSION: In a cohort of 150 patients with SVR followed for 5 years, the majority of patients had good outcomes. Serum virologic relapse was not seen, but two patients with pretreatment cirrhosis developed HCC, and one died. In a blind rescoring of 49 paired pretreatment and long-term follow-up biopsies, 82% improved fibrosis scores and 92% improved at least one component of inflammation. A minority of patients had normal or nearly normal liver tissue on long-term follow-up biopsy. Patients with cirrhosis pretreatment are at a low but real risk of HCC after SVR. | lld:pubmed |
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| pubmed-article:19072828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19072828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19072828 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19072828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19072828 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19072828 | pubmed:issn | 1527-3350 | lld:pubmed |
| pubmed-article:19072828 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:19072828 | pubmed:author | pubmed-author:BaconBruce... | lld:pubmed |
| pubmed-article:19072828 | pubmed:author | pubmed-author:BruntElizabet... | lld:pubmed |
| pubmed-article:19072828 | pubmed:author | pubmed-author:GeorgeSarah... | lld:pubmed |
| pubmed-article:19072828 | pubmed:author | pubmed-author:Mihindukulasu... | lld:pubmed |
| pubmed-article:19072828 | pubmed:author | pubmed-author:HoffmannJoyce... | lld:pubmed |
| pubmed-article:19072828 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19072828 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:19072828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19072828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19072828 | pubmed:pagination | 729-38 | lld:pubmed |
| pubmed-article:19072828 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:19072828 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19072828 | pubmed:articleTitle | Clinical, virologic, histologic, and biochemical outcomes after successful HCV therapy: a 5-year follow-up of 150 patients. | lld:pubmed |
| pubmed-article:19072828 | pubmed:affiliation | Department of Internal Medicine, Division of Gastroenterology, Saint Louis University Liver Center, St Louis, MO, USA. georgesl@slu.edu | lld:pubmed |
| pubmed-article:19072828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19072828 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:19072828 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19072828 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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