| pubmed-article:19070575 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19070575 | lifeskim:mentions | umls-concept:C0205101 | lld:lifeskim |
| pubmed-article:19070575 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:19070575 | lifeskim:mentions | umls-concept:C0242609 | lld:lifeskim |
| pubmed-article:19070575 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:19070575 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:19070575 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:19070575 | lifeskim:mentions | umls-concept:C1999230 | lld:lifeskim |
| pubmed-article:19070575 | lifeskim:mentions | umls-concept:C0332158 | lld:lifeskim |
| pubmed-article:19070575 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19070575 | pubmed:dateCreated | 2008-12-16 | lld:pubmed |
| pubmed-article:19070575 | pubmed:abstractText | Kinetochore specification and assembly requires the targeted deposition of specialized nucleosomes containing the histone H3 variant CENP-A at centromeres. However, CENP-A is not sufficient to drive full-kinetochore assembly, and it is not clear how centromeric chromatin is established. Here, we identify CENP-W as a component of the DNA-proximal constitutive centromere-associated network (CCAN) of proteins. We demonstrate that CENP-W forms a DNA-binding complex together with the CCAN component CENP-T. This complex directly associates with nucleosomal DNA and with canonical histone H3, but not with CENP-A, in centromeric regions. CENP-T/CENP-W functions upstream of other CCAN components with the exception of CENP-C, an additional putative DNA-binding protein. Our analysis indicates that CENP-T/CENP-W and CENP-C provide distinct pathways to connect the centromere with outer kinetochore assembly. In total, our results suggest that the CENP-T/CENP-W complex is directly involved in establishment of centromere chromatin structure coordinately with CENP-A. | lld:pubmed |
| pubmed-article:19070575 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19070575 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19070575 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19070575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19070575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19070575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19070575 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19070575 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19070575 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19070575 | pubmed:issn | 1097-4172 | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:OkawaKatsuyaK | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:CheesemanIain... | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:SuzukiEmikoE | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:FukagawaTatsu... | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:McEwenBruce... | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:HoriTetsuyaT | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:BackerChelsea... | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:AmanoMihoM | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:DongYiminY | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:ShangWei-HaoW... | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:SuzukiAussieA | lld:pubmed |
| pubmed-article:19070575 | pubmed:author | pubmed-author:WelburnJulie... | lld:pubmed |
| pubmed-article:19070575 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19070575 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:19070575 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:19070575 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19070575 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19070575 | pubmed:pagination | 1039-52 | lld:pubmed |
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| pubmed-article:19070575 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:19070575 | pubmed:articleTitle | CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. | lld:pubmed |
| pubmed-article:19070575 | pubmed:affiliation | Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka 411-8540, Japan. | lld:pubmed |
| pubmed-article:19070575 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19070575 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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